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Fbp2 Gene Detail
Summary
  • Symbol
    Fbp2
  • Name
    fructose bisphosphatase 2
  • Synonyms
    Fbp-1, FBPase muscle
  • Feature Type
    protein coding gene
  • IDs
    MGI:95491
    NCBI Gene: 14120
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:62984698-63006214 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 32.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    853 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95491
 protein coding gene Chr13:62984691-63006236 (-)
129S1/SvImJ ENSMUSG00200015126
 protein coding gene Chr13:59106544-59128191 (-)
A/J ENSMUSG00195043558
 protein coding gene Chr13:59261262-59283031 (-)
AKR/J ENSMUSG00220040315
 protein coding gene Chr13:58334644-58356194 (-)
BALB/cJ ENSMUSG00180014941
 protein coding gene Chr13:59579530-59601195 (-)
C3H/HeJ ENSMUSG00175036815
 protein coding gene Chr13:59392565-59414113 (-)
C57BL/6NJ ENSMUSG00215038286
 protein coding gene Chr13:59394984-59416532 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018630
 protein coding gene Chr13:58190128-58211608 (-)
CAST/EiJ ENSTCUG00005039522
 protein coding gene Chr13:59779345-59800952 (-)
CBA/J ENSMUSG00210031586
 protein coding gene Chr13:59592043-59613591 (-)
DBA/2J ENSMUSG00185006903
 protein coding gene Chr13:60440663-60462210 (-)
FVB/NJ ENSMUSG00205040915
 protein coding gene Chr13:58566659-58588562 (-)
JF1/MsJ ENSUMUG00000011670
 protein coding gene Chr13:60064619-60086333 (-)
LP/J ENSMUSG00230029834
 protein coding gene Chr13:69782714-69804380 (-)
NOD/ShiLtJ ENSMUSG00190026825
 protein coding gene Chr13:59348047-59369704 (-)
NZO/HlLtJ ENSMUSG00225046757
 protein coding gene Chr13:63491928-63513473 (-)
PWK/PhJ ENSLUMG00010022211
 protein coding gene Chr13:58898149-58919768 (-)
SPRET/EiJ ENSMSPG00010040876
 protein coding gene Chr13:59121488-59143206 (-)
WSB/EiJ ENSIUOG00005025098
 protein coding gene Chr13:58078529-58100225 (-)



Homology
more
  • Human Ortholog
    FBP2, fructose-bisphosphatase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBP2, fructose-bisphosphatase 2
  • Synonyms
    CORLK
  • Links
    NCBI Gene ID: 8789
    UniProt: O00757

  • Chr Location
    9q22.32; chr9:94558720-94593824 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
This locus controls electrophoretic variation of fructose bisphosphatase isozymes in muscle. Isozymes of kidney, liver and testis are not affected. P, SEA, SWR and Peru-Coppock have a slow migrating band; SM, C3H/He, C57BL/Go, CE and DBA/2 have a fast migrating band. Heterozygotes are intermediate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    198
  • cDNA Data
    34
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14120 NCBI Gene Model | MGI Sequence Detail 21517 C57BL/6J ±  kb
    transcript NM_007994 RefSeq | MGI Sequence Detail 1325 C57BL/6  
    polypeptide P70695 UniProt | EBI | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 1
      cDNA 34
      Primer pair 2
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9719, MGD-MRK-9721
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory