About   Help   FAQ
Fbl Gene Detail
Summary
  • Symbol
    Fbl
  • Name
    fibrillarin
  • Synonyms
    RNU3IP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95486
    NCBI Gene: 14113
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:27869135-27878694 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.67 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    252 from dbSNP Build 142
  • Strain Annotations
    24
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95486
 protein coding gene Chr7:27868293-27878701 (+)
129S1/SvImJ ENSMUSG00200001097
 protein coding gene Chr3:67402195-67403367 (-)
129S1/SvImJ ENSMUSG00200040724
 protein coding gene Chr7:17654928-17664487 (+)
A/J ENSMUSG00195048920
 protein coding gene Chr7:20326186-20335746 (+)
A/J ENSMUSG00195026008
 protein coding gene Chr3:67503023-67504195 (-)
AKR/J ENSMUSG00220049970
 protein coding gene Chr7:24148258-24157817 (-)
AKR/J ENSMUSG00220024564
 protein coding gene Chr3:67499298-67500470 (-)
BALB/cJ ENSMUSG00180008169
 protein coding gene Chr3:67583746-67584918 (-)
BALB/cJ ENSMUSG00180049850
 protein coding gene Chr7:18385730-18395290 (+)
C3H/HeJ ENSMUSG00175051575
 protein coding gene Chr7:19429011-19438570 (+)
C57BL/6NJ ENSMUSG00215054181
 protein coding gene Chr7:17558926-17568485 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029434
 protein coding gene Chr7:27385032-27394304 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210002024
 protein coding gene Chr3:67511512-67512684 (-)
CBA/J ENSMUSG00210051933
 protein coding gene Chr7:18613616-18623176 (+)
DBA/2J ENSMUSG00185045061
 protein coding gene Chr7:21720586-21730145 (+)
DBA/2J ENSMUSG00185014873
 protein coding gene Chr3:67660088-67661260 (-)
FVB/NJ ENSMUSG00205044760
 protein coding gene Chr7:18393185-18402752 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230001670
 protein coding gene Chr3:69688948-69690120 (-)
LP/J ENSMUSG00230053631
 protein coding gene Chr7:26891138-26900697 (+)
NOD/ShiLtJ ENSMUSG00190051793
 protein coding gene Chr7:18054867-18064426 (+)
NZO/HlLtJ ENSMUSG00225024270
 protein coding gene Chr7:25734230-25743789 (+)
NZO/HlLtJ ENSMUSG00225004364
 protein coding gene Chr3:72371581-72372753 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010037201
 protein coding gene Chr7:17449415-17458981 (+)
WSB/EiJ ENSIUOG00005050464
 protein coding gene Chr7:12321625-12331183 (+)



Homology
more
  • Human Ortholog
    FBL, fibrillarin rRNA 2'-O-methyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBL, fibrillarin rRNA 2'-O-methyltransferase
  • Synonyms
    FIB, FLRN, Nop1, RNU3IP1
  • Links
    NCBI Gene ID: 2091
    UniProt: P22087

  • Chr Location
    19q13.2; chr19:39834453-39846440 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with morula arrest. Heterozygous null mice display partial embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    682
  • Tissues
    35
  • cDNA Data
    12
  • Literature Summary
    29
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046865 Ensembl Gene Model | MGI Sequence Detail 9560 C57BL/6J ±  kb
transcript ENSMUST00000042405 Ensembl | MGI Sequence Detail 1197 Not Applicable  
polypeptide ENSMUSP00000037613 Ensembl | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007356 rRNA 2'-O-methyltransferase fibrillarin
    (term hierarchy)
  • EC
    2.1.1.-
  • InterPro Domains
    IPR020813 Fibrillarin, conserved site
    IPR000692 rRNA 2'-O-methyltransferase fibrillarin-like
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
  • GlyGen
    P35550 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 17
    cDNA 14
    Primer pair 2
    Other 1
    Antibodies 8

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-9714, MGI:2146948
References
more
  • Summaries
    All 84
    Developmental Gene Expression 29
    Gene Ontology 25
    Phenotypes 10
  • Earliest
    J:20648 Aris JP, et al., cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):931-5
  • Latest
    J:379330 Jiang Y, et al., Multi-omics analysis the effects of Dhx37 deficiency on testis development and nucleolar homeostasis. Cell Death Discov. 2026 Jan 14;12(1):77
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory