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Dpep1 Gene Detail
Summary
  • Symbol
    Dpep1
  • Name
    dipeptidase 1
  • Synonyms
    MBD
  • Feature Type
    protein coding gene
  • IDs
    MGI:94917
    NCBI Gene: 13479
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123913069-123928551 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.08 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    613 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94917
 protein coding gene Chr8:123912981-123928551 (+)
129S1/SvImJ ENSMUSG00200042632
 protein coding gene Chr8:118243508-118259088 (+)
A/J ENSMUSG00195026078
 protein coding gene Chr8:118537430-118552637 (+)
AKR/J ENSMUSG00220037926
 protein coding gene Chr8:118725683-118741363 (+)
BALB/cJ ENSMUSG00180023172
 protein coding gene Chr8:118583436-118598647 (+)
C3H/HeJ ENSMUSG00175029725
 protein coding gene Chr8:118637594-118653271 (+)
C57BL/6NJ ENSMUSG00215023833
 protein coding gene Chr8:118219280-118234851 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031679
 protein coding gene Chr8:114340611-114360357 (+)
CAST/EiJ ENSTCUG00005030823
 protein coding gene Chr8:117956298-117971615 (+)
CBA/J ENSMUSG00210031994
 protein coding gene Chr8:118571712-118587283 (+)
DBA/2J ENSMUSG00185033275
 protein coding gene Chr8:124676651-124692224 (+)
FVB/NJ ENSMUSG00205023916
 protein coding gene Chr8:117537938-117553516 (+)
JF1/MsJ ENSUMUG00000018391
 protein coding gene Chr8:126977106-126992312 (+)
LP/J ENSMUSG00230028087
 protein coding gene Chr8:128294921-128310496 (+)
NOD/ShiLtJ ENSMUSG00190017967
 protein coding gene Chr8:118672191-118687765 (+)
NZO/HlLtJ ENSMUSG00225041631
 protein coding gene Chr8:131677123-131692696 (+)
PWK/PhJ ENSLUMG00010031496
 protein coding gene Chr8:118381388-118396666 (+)
SPRET/EiJ ENSMSPG00010036050
 protein coding gene Chr8:120563509-120578755 (+)
WSB/EiJ ENSIUOG00005027257
 protein coding gene Chr8:119357234-119372817 (+)



Homology
more
  • Human Ortholog
    DPEP1, dipeptidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPEP1, dipeptidase 1
  • Synonyms
    MBD1, MDP, RDP
  • Links
    NCBI Gene ID: 1800
    UniProt: P16444

  • Chr Location
    16q24.3; chr16:89613308-89641540 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DPEP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Mice homozygous for disruption of this gene ar phenotypically normal although defects have been noted in the conversion of leukotriene D4 to leukotrience E4.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    96
  • cDNA Data
    10
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13479 NCBI Gene Model | MGI Sequence Detail 15483 C57BL/6J ±  kb
transcript NM_007876 RefSeq | MGI Sequence Detail 2148 ZRU/MplStud  
polypeptide P31428 UniProt | EBI | MGI Sequence Detail 410 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-8882, MGI:2142515
References
more
  • Summaries
    All 53
    Developmental Gene Expression 6
    Gene Ontology 12
    Phenotypes 11
  • Earliest
    J:12584 Satoh S, et al., Purification and molecular cloning of mouse renal dipeptidase. Biochim Biophys Acta. 1993 Jun 4;1163(3):234-42
  • Latest
    J:371104 Hoyt LR, et al., Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice. Science. 2025 Aug 7;389(6760):eadp0240
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory