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Pa2g4 Gene Detail
Summary
  • Symbol
    Pa2g4
  • Name
    proliferation-associated 2G4
  • Synonyms
    Ebp1, Plfap
  • Feature Type
    protein coding gene
  • IDs
    MGI:894684
    NCBI Gene: 18813
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128393635-128401803 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 77.09 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894684
 protein coding gene Chr10:128393635-128401856 (-)
129S1/SvImJ ENSMUSG00200010877
 protein coding gene Chr10:124751750-124759969 (-)
A/J ENSMUSG00195013759
 protein coding gene Chr10:125215029-125223248 (-)
AKR/J ENSMUSG00220004483
 protein coding gene Chr10:124820445-124828656 (-)
BALB/cJ ENSMUSG00180011012
 protein coding gene Chr10:125205993-125214212 (-)
C3H/HeJ ENSMUSG00175006129
 protein coding gene Chr10:125205381-125213598 (-)
C57BL/6NJ ENSMUSG00215009535
 protein coding gene Chr10:124812088-124820307 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015944
 protein coding gene Chr10:120919238-120926426 (-)
CAST/EiJ ENSTCUG00005035361
 protein coding gene Chr10:124197104-124205341 (-)
CBA/J ENSMUSG00210008810
 protein coding gene Chr10:125029601-125037818 (-)
DBA/2J ENSMUSG00185023031
 protein coding gene Chr10:125179235-125187454 (-)
FVB/NJ ENSMUSG00205024081
 protein coding gene Chr10:124420600-124428823 (-)
JF1/MsJ ENSUMUG00000023851
 protein coding gene Chr10:126489175-126497411 (-)
LP/J ENSMUSG00230029083
 protein coding gene Chr10:127105001-127113206 (-)
NOD/ShiLtJ ENSMUSG00190014622
 protein coding gene Chr10:125242859-125251078 (-)
NZO/HlLtJ ENSMUSG00225036419
 protein coding gene Chr10:131303798-131312017 (-)
PWK/PhJ ENSLUMG00010009231
 protein coding gene Chr10:124941352-124949569 (-)
SPRET/EiJ ENSMSPG00010031507
 protein coding gene Chr10:126903729-126911909 (-)
WSB/EiJ ENSIUOG00005008347
 protein coding gene Chr10:124826505-124834741 (-)



Homology
more
  • Human Ortholog
    PA2G4, proliferation-associated 2G4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PA2G4, proliferation-associated 2G4
  • Synonyms
    EBP1, HG4-1, ITAF45, p38-2G4
  • Links
    NCBI Gene ID: 5036
    UniProt: Q9UQ80

  • Chr Location
    12q13.2; chr12:56104349-56116329 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased body size and weight during early adulthood and produce smaller than normal litters.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    620
  • Tissues
    23
  • cDNA Data
    23
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18813 NCBI Gene Model | MGI Sequence Detail 8169 C57BL/6J ±  kb
    transcript NM_011119 RefSeq | MGI Sequence Detail 2432 C57BL/6  
    polypeptide P50580 UniProt | EBI | MGI Sequence Detail 394 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 23
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2143505
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:29067 Radomski N, et al., Molecular cloning of a murine cDNA encoding a novel protein, p38-2G4, which varies with the cell cycle. Exp Cell Res. 1995 Oct;220(2):434-45
    • Latest
      J:373076 Krishan S, et al., PA2G4 Functions as a Cofactor for MYC Family Oncoproteins in MYC-Driven Malignancies. Cells. 2025 Sep 11;14(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory