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Mal Gene Detail
Summary
  • Symbol
    Mal
  • Name
    myelin and lymphocyte protein, T cell differentiation protein
  • Synonyms
    VIP17
  • Feature Type
    protein coding gene
  • IDs
    MGI:892970
    NCBI Gene: 17153
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:127475146-127498615 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 62.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    632 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892970
 protein coding gene Chr2:127475146-127498615 (-)
129S1/SvImJ ENSMUSG00200048266
 protein coding gene Chr2:124529213-124552660 (-)
A/J ENSMUSG00195029228
 protein coding gene Chr2:124557407-124580889 (-)
AKR/J ENSMUSG00220042352
 protein coding gene Chr2:124323006-124346455 (-)
BALB/cJ ENSMUSG00180044414
 protein coding gene Chr2:124346457-124369945 (-)
C3H/HeJ ENSMUSG00175042919
 protein coding gene Chr2:124893594-124917043 (-)
C57BL/6NJ ENSMUSG00215013521
 protein coding gene Chr2:124396490-124419957 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024263
 protein coding gene Chr2:120468333-120492475 (-)
CAST/EiJ ENSTCUG00005037144
 protein coding gene Chr2:123687829-123711274 (-)
CBA/J ENSMUSG00210033554
 protein coding gene Chr2:124744021-124767473 (-)
DBA/2J ENSMUSG00185030736
 protein coding gene Chr2:124398082-124421538 (-)
FVB/NJ ENSMUSG00205023501
 protein coding gene Chr2:123552337-123575786 (-)
JF1/MsJ ENSUMUG00000006515
 protein coding gene Chr2:124248431-124271983 (-)
LP/J ENSMUSG00230033078
 protein coding gene Chr2:126164634-126188085 (-)
NOD/ShiLtJ ENSMUSG00190012300
 protein coding gene Chr2:124522422-124545870 (-)
NZO/HlLtJ ENSMUSG00225027422
 protein coding gene Chr2:134070819-134094266 (-)
PWK/PhJ ENSLUMG00010038121
 protein coding gene Chr2:124138568-124162550 (-)
SPRET/EiJ ENSMSPG00010029270
 protein coding gene Chr2:126563696-126587539 (-)
WSB/EiJ ENSIUOG00005038957
 protein coding gene Chr2:124339551-124363036 (-)



Homology
more
  • Human Ortholog
    MAL, mal, T cell differentiation protein (MAL blood group)
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAL, mal, T cell differentiation protein (MAL blood group)
  • Synonyms
    HLD28, MVP17, VIP17
  • Links
    NCBI Gene ID: 4118
    UniProt: P21145

  • Chr Location
    2q11.1; chr2:95025677-95054932 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MAL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal myelination and optic nerve morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    677
  • Tissues
    37
  • cDNA Data
    37
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17153 NCBI Gene Model | MGI Sequence Detail 23470 C57BL/6J ±  kb
    transcript NM_010762 RefSeq | MGI Sequence Detail 2792 C57BL/6  
    polypeptide O09198 UniProt | EBI | MGI Sequence Detail 153 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 4
      cDNA 37

      Microarray probesets 4
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory