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Col10a1 Gene Detail
Summary
  • Symbol
    Col10a1
  • Name
    collagen, type X, alpha 1
  • Synonyms
    Col10, Col10a-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88445
    NCBI Gene: 12813
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
  • Regulated by
    Rr582 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr10:34265977-34273081 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 18.85 cM, cytoband B1-B3
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88445
 protein coding gene Chr10:34265977-34273081 (+)
129S1/SvImJ ENSMUSG00200007748
 protein coding gene Chr10:31110902-31118010 (+)
A/J ENSMUSG00195015101
 protein coding gene Chr10:31387024-31394126 (+)
AKR/J ENSMUSG00220027352
 protein coding gene Chr10:31084294-31091402 (+)
BALB/cJ ENSMUSG00180015417
 protein coding gene Chr10:31507044-31514148 (+)
C3H/HeJ ENSMUSG00175011544
 protein coding gene Chr10:31262056-31269162 (+)
C57BL/6NJ ENSMUSG00215007571
 protein coding gene Chr10:31051700-31058802 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015236
 protein coding gene Chr10:30204825-30211880 (+)
CAST/EiJ ENSTCUG00005025902
 protein coding gene Chr10:31507752-31514950 (+)
CBA/J ENSMUSG00210025171
 protein coding gene Chr10:31189390-31196498 (+)
DBA/2J ENSMUSG00185006584
 protein coding gene Chr10:31342214-31349326 (+)
FVB/NJ ENSMUSG00205011186
 protein coding gene Chr10:31323055-31330161 (+)
JF1/MsJ ENSUMUG00000023684
 protein coding gene Chr10:31126302-31133407 (+)
LP/J ENSMUSG00230014098
 protein coding gene Chr10:33107784-33114890 (+)
NOD/ShiLtJ ENSMUSG00190026799
 protein coding gene Chr10:31455246-31462352 (+)
NZO/HlLtJ ENSMUSG00225033258
 protein coding gene Chr10:37366173-37373277 (+)
PWK/PhJ ENSLUMG00010007518
 protein coding gene Chr10:31138310-31145400 (+)
SPRET/EiJ ENSMSPG00010019083
 protein coding gene Chr10:32080015-32087071 (+)
WSB/EiJ ENSIUOG00005013967
 protein coding gene Chr10:30895921-30903035 (+)



Homology
more
  • Human Ortholog
    COL10A1, collagen type X alpha 1 chain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COL10A1, collagen type X alpha 1 chain
  • Links
    NCBI Gene ID: 1300
    UniProt: Q03692

  • Chr Location
    6q22.1; chr6:116118909-116217144 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Col10a1 mouse models; 2 with human COL10A1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 5 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    5 images
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations may exhibit abnormal trabecular bone, thinner growth plate resting zone and articular cartilage, and altered bone content. Mice homozygous for another knock-out allele exhibit altered B and T cell populations and TH1/TH2responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1501
  • Tissues
    228
  • cDNA Data
    30
  • Literature Summary
    534
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12813 NCBI Gene Model | MGI Sequence Detail 7105 C57BL/6J ±  kb
    transcript NM_009925 RefSeq | MGI Sequence Detail 3139 ZRU/MplStud  
    polypeptide Q05306 UniProt | EBI | MGI Sequence Detail 680 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 138
      Genomic 21
      cDNA 42
      Primer pair 15
      Other 60
      Antibodies 34

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2051, MGD-MRK-2052
    References
    more
    • Summaries
      All 636
      Developmental Gene Expression 534
      Diseases 2
      Gene Ontology 12
      Phenotypes 48
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:388883 Amano K, et al., The role of Pth1r in posterior cranium cartilage regulation and craniosynostosis. Nat Commun. 2026 Apr 28;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory