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Chgb Gene Detail
Summary
  • Symbol
    Chgb
  • Name
    chromogranin B
  • Synonyms
    Scg-1, secretogranin I
  • Feature Type
    protein coding gene
  • IDs
    MGI:88395
    NCBI Gene: 12653
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:132623562-132636999 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 64.74 cM, cytoband F-G
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    473 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88395
 protein coding gene Chr2:132623198-132636999 (+)
129S1/SvImJ ENSMUSG00200046459
 protein coding gene Chr2:129675382-129689176 (+)
A/J ENSMUSG00195027751
 protein coding gene Chr2:129701240-129715042 (+)
AKR/J ENSMUSG00220044041
 protein coding gene Chr2:129473532-129487341 (+)
BALB/cJ ENSMUSG00180045528
 protein coding gene Chr2:129519783-129533585 (+)
C3H/HeJ ENSMUSG00175040530
 protein coding gene Chr2:130062152-130075960 (+)
C57BL/6NJ ENSMUSG00215026448
 protein coding gene Chr2:129549163-129562963 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024343
 protein coding gene Chr2:125566786-125580147 (+)
CAST/EiJ ENSTCUG00005033638
 protein coding gene Chr2:128830869-128844631 (+)
CBA/J ENSMUSG00210030649
 protein coding gene Chr2:129918613-129932417 (+)
DBA/2J ENSMUSG00185034711
 protein coding gene Chr2:129561015-129574817 (+)
FVB/NJ ENSMUSG00205032441
 protein coding gene Chr2:128735241-128749040 (+)
JF1/MsJ ENSUMUG00000008131
 protein coding gene Chr2:129378645-129392466 (+)
LP/J ENSMUSG00230038210
 protein coding gene Chr2:131311662-131325470 (+)
NOD/ShiLtJ ENSMUSG00190013165
 protein coding gene Chr2:129642228-129656031 (+)
NZO/HlLtJ ENSMUSG00225027003
 protein coding gene Chr2:139220154-139233955 (+)
PWK/PhJ ENSLUMG00010040848
 protein coding gene Chr2:129382529-129396461 (+)
SPRET/EiJ ENSMSPG00010026153
 protein coding gene Chr2:131753789-131767650 (+)
WSB/EiJ ENSIUOG00005041176
 protein coding gene Chr2:129489754-129503546 (+)



Homology
more
  • Human Ortholog
    CHGB, chromogranin B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHGB, chromogranin B
  • Synonyms
    SCG1
  • Links
    NCBI Gene ID: 1114
    UniProt: P05060

  • Chr Location
    20p12.3; chr20:5911394-5925361 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced catecholamine secretion from adrenal chromaffin cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    104
  • cDNA Data
    63
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12653 NCBI Gene Model | MGI Sequence Detail 13438 C57BL/6J ±  kb
    transcript NM_007694 RefSeq | MGI Sequence Detail 2376 ZRU/MplStud  
    polypeptide P16014 UniProt | EBI | MGI Sequence Detail 677 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 1
      cDNA 66
      Primer pair 5
      Other 3
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14309, MGD-MRK-1970
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 33
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:354356 Zhang Y, et al., Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is Essential for the Establishment of Neuronal Polarity and Brain Formation. J Neurosci. 2024 Jul 3;44(27)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory