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Ccnd3 Gene Detail
Summary
  • Symbol
    Ccnd3
  • Name
    cyclin D3
  • Synonyms
    9230106B05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88315
    NCBI Gene: 12445
  • Alliance
  • Transcription Start Sites
    64 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:47815976-47910614 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 23.37 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2673 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88315
protein coding gene Chr17:47815976-47910616 (+)
129S1/SvImJ ENSMUSG00200027309
protein coding gene Chr17:43112699-43113789 (+)
129S1/SvImJ ENSMUSGG00200054678
protein coding gene Chr17:43019207-43112275 (+)
A/J ENSMUSG00195020971
protein coding gene Chr17:44612403-44613493 (+)
A/J ENSMUSGG00195055070
protein coding gene Chr17:44519227-44611979 (+)
AKR/J ENSMUSG00220033879
protein coding gene Chr17:43612403-43613493 (+)
AKR/J ENSMUSGG00220054424
protein coding gene Chr17:43512937-43611979 (+)
BALB/cJ ENSMUSG00180020808
protein coding gene Chr17:44368741-44369831 (+)
BALB/cJ ENSMUSGG00180055106
protein coding gene Chr17:44269260-44368317 (+)
C3H/HeJ ENSMUSGG00175055036
protein coding gene Chr17:43583174-43675898 (+)
C3H/HeJ ENSMUSG00175015377
protein coding gene Chr17:43676322-43677412 (+)
C57BL/6NJ ENSMUSGG00215055293
protein coding gene Chr17:43139240-43232038 (+)
C57BL/6NJ ENSMUSG00215018119
protein coding gene Chr17:43232462-43233553 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021702
protein coding gene Chr17:44207872-44304461 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054774
protein coding gene Chr17:43332815-43425531 (+)
CBA/J ENSMUSG00210029136
protein coding gene Chr17:43425955-43427045 (+)
DBA/2J ENSMUSG00185029181
protein coding gene Chr17:46324930-46326020 (+)
DBA/2J ENSMUSGG00185057371
protein coding gene Chr17:46231784-46324506 (+)
FVB/NJ ENSMUSG00205025455
protein coding gene Chr17:43929489-43930579 (+)
FVB/NJ ENSMUSGG00205054531
protein coding gene Chr17:43836541-43929065 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055552
protein coding gene Chr17:47130781-47223838 (+)
LP/J ENSMUSG00230037619
protein coding gene Chr17:47224262-47225352 (+)
NOD/ShiLtJ ENSMUSGG00190054767
protein coding gene Chr17:43227167-43320030 (+)
NOD/ShiLtJ ENSMUSG00190017290
protein coding gene Chr17:43320454-43321544 (+)
NZO/HlLtJ ENSMUSG00225041979
protein coding gene Chr17:49477562-49478652 (+)
NZO/HlLtJ ENSMUSGG00225055395
protein coding gene Chr17:49384439-49477138 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010028950
protein coding gene Chr17:43381877-43388078 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CCND3, cyclin D3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCND3, cyclin D3
  • Links
    NCBI Gene ID: 896
    UniProt: P30281

  • Chr Location
    6p21.1; chr6:41934933-42050357 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 4 genetic backgrounds
    31 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit severe thymus hypoplasia, abnormal thymocyte development, and impaired expansion of immature T lymphocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12445 NCBI Gene Model | MGI Sequence Detail 94639 C57BL/6J ±  kb
    transcript NM_001081636 RefSeq | MGI Sequence Detail 2131 ZRU/MplStud  
    polypeptide P30282 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 29
      Primer pair 11
      Other 6
      Antibodies 9

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1827, MGI:1924959, MGI:2146781, MGI:2146960, MGI:2147051, MGI:2147125
    References
    more
    • Summaries
      All 273
      Developmental Gene Expression 118
      Gene Ontology 16
      Phenotypes 48
    • Earliest
      J:14776 Matsushime H, et al., Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell. 1991 May 17;65(4):701-13
    • Latest
      J:390294 Mucha B, et al., Stage-Specific Degradation of Cyclin D3 Orchestrates Myelopoiesis and Restrains Myeloproliferative Neoplasms Development. Cancer Res. 2026 Jun 1;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory