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Cbr1 Gene Detail
Summary
  • Symbol
    Cbr1
  • Name
    carbonyl reductase 1
  • Synonyms
    CR
  • Feature Type
    protein coding gene
  • IDs
    MGI:88284
    NCBI Gene: 12408
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:93404752-93407226 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 54.53 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88284
 protein coding gene Chr16:93402741-93407393 (+)
129S1/SvImJ ENSMUSG00200036973
 protein coding gene Chr16:90335023-90340738 (+)
A/J ENSMUSG00195027965
 protein coding gene Chr16:90092773-90098495 (+)
AKR/J ENSMUSG00220015593
 protein coding gene Chr16:90338016-90343768 (+)
BALB/cJ ENSMUSG00180013842
 protein coding gene Chr16:90166753-90172467 (+)
C3H/HeJ ENSMUSG00175014994
 protein coding gene Chr16:90503923-90509639 (+)
C57BL/6NJ ENSMUSG00215023308
 protein coding gene Chr16:90291709-90297186 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020980
 protein coding gene Chr16:88008717-88011404 (+)
CAST/EiJ ENSTCUG00005018072
 protein coding gene Chr16:89860739-89917224 (+)
CBA/J ENSMUSG00210033310
 protein coding gene Chr16:90411435-90417155 (+)
DBA/2J ENSMUSG00185032723
 protein coding gene Chr16:90350845-90356563 (+)
FVB/NJ ENSMUSG00205020352
 protein coding gene Chr16:90130339-90136055 (+)
JF1/MsJ ENSUMUG00000015332
 protein coding gene Chr16:90517520-90520187 (+)
LP/J ENSMUSG00230024519
 protein coding gene Chr16:92881680-92887394 (+)
NOD/ShiLtJ ENSMUSG00190024358
 protein coding gene Chr16:90319335-90325050 (+)
NZO/HlLtJ ENSMUSG00225030065
 protein coding gene Chr16:96006431-96011918 (+)
PWK/PhJ ENSLUMG00010013311
 protein coding gene Chr16:90156546-90159215 (+)
SPRET/EiJ ENSMSPG00010019797
 protein coding gene Chr16:91261059-91263745 (+)
WSB/EiJ ENSIUOG00005017915
 protein coding gene Chr16:90240152-90242822 (+)



Homology
more
  • Human Ortholog
    CBR1, carbonyl reductase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBR1, carbonyl reductase 1
  • Synonyms
    CBR, hCBR1, PG-9-KR, SDR21C1
  • Links
    NCBI Gene ID: 873
    UniProt: P16152

  • Chr Location
    21q22.12; chr21:36069941-36073166 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from multigenic genotypes
    95 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    132
  • cDNA Data
    83
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12408 NCBI Gene Model | MGI Sequence Detail 2475 C57BL/6J ±  kb
transcript NM_007620 RefSeq | MGI Sequence Detail 1043 ZRU/MplStud  
polypeptide P48758 UniProt | EBI | MGI Sequence Detail 277 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 91
    Genomic 4
    cDNA 83
    Primer pair 2
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1787, MGI:2146635
References
more
  • Summaries
    All 143
    Developmental Gene Expression 3
    Diseases 6
    Gene Ontology 11
    Phenotypes 95
  • Earliest
    J:2142 Brookes S, et al., Localization of four human chromosome 21 genes--SOD1, ETS2, IFNAR, and CBR--to two different chromosomes in the marsupial species Macropus eugenii. Cytogenet Cell Genet. 1992;61(1):25-8
  • Latest
    J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory