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Ctnna1 Gene Detail
Summary
  • Symbol
    Ctnna1
  • Name
    catenin alpha 1
  • Synonyms
    2010010M04Rik, alpha E catenin, alpha(E)-catenin, catenin (cadherin associated protein), alpha 1, Catna1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88274
    NCBI Gene: 12385
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35251955-35387829 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 18.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2558 from dbSNP Build 142
  • Strain Annotations
    27
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88274
 protein coding gene Chr18:35251912-35387832 (+)
129S1/SvImJ ENSMUSG00200040762
 protein coding gene Chr18:32353663-32371070 (+)
129S1/SvImJ ENSMUSGG00200054404
 protein coding gene Chr18:32284190-32306010 (+)
A/J ENSMUSGG00195054924
 protein coding gene Chr18:32450882-32472700 (+)
A/J ENSMUSG00195034009
 protein coding gene Chr18:32520347-32537754 (+)
AKR/J ENSMUSGG00220054389
 protein coding gene Chr18:32427179-32449016 (+)
AKR/J ENSMUSG00220017099
 protein coding gene Chr18:32496663-32514076 (+)
BALB/cJ ENSMUSG00180015994
 protein coding gene Chr18:32970000-32987414 (+)
BALB/cJ ENSMUSGG00180055208
 protein coding gene Chr18:32900520-32922344 (+)
C3H/HeJ ENSMUSG00175030153
 protein coding gene Chr18:32472565-32489968 (+)
C3H/HeJ ENSMUSGG00175054607
 protein coding gene Chr18:32402848-32424676 (+)
C57BL/6NJ ENSMUSG00215020241
 protein coding gene Chr18:32223780-32241190 (+)
C57BL/6NJ ENSMUSGG00215055345
 protein coding gene Chr18:32154306-32176127 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022104
 protein coding gene Chr18:32384566-32516134 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210019954
 protein coding gene Chr18:32512191-32529598 (+)
CBA/J ENSMUSGG00210054511
 protein coding gene Chr18:32442718-32464536 (+)
DBA/2J ENSMUSGG00185057497
 protein coding gene Chr18:32377252-32399072 (+)
DBA/2J ENSMUSG00185020300
 protein coding gene Chr18:32446725-32464133 (+)
FVB/NJ ENSMUSG00205019297
 protein coding gene Chr18:32158564-32175976 (+)
FVB/NJ ENSMUSGG00205054555
 protein coding gene Chr18:32089087-32110907 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230048423
 protein coding gene Chr18:34550483-34567889 (+)
LP/J ENSMUSGG00230055529
 protein coding gene Chr18:34481006-34502834 (+)
NOD/ShiLtJ ENSMUSG00190017928
 protein coding gene Chr18:32226379-32243787 (+)
NOD/ShiLtJ ENSMUSGG00190054985
 protein coding gene Chr18:32156662-32178485 (+)
NZO/HlLtJ ENSMUSGG00225055261
 protein coding gene Chr18:34385794-34407614 (+)
NZO/HlLtJ ENSMUSG00225045874
 protein coding gene Chr18:34455264-34472670 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010018520
 protein coding gene Chr18:32687865-32821607 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CTNNA1, catenin alpha 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTNNA1, catenin alpha 1
  • Synonyms
    CAP102, MDBS2, MDPT2
  • Links
    NCBI Gene ID: 1495
    UniProt: P35221

  • Chr Location
    5q31.2; chr5:138610967-138935039 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ctnna1 mouse models; 1 with human CTNNA1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 5 alleles in 8 genetic backgrounds
    11 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality at the blastocyst stage. A conditional knockout in surface epithelium results in defects in hair follicle development and epidermal morphogenesis. Inducible KO in endothelial cells reduces lifespan and affects retinal angiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    93
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    854
  • Tissues
    221
  • cDNA Data
    471
  • Literature Summary
    86
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12385 NCBI Gene Model | MGI Sequence Detail 135875 C57BL/6J ±  kb
    transcript NM_009818 RefSeq | MGI Sequence Detail 3713 129/Sv  
    polypeptide P26231 UniProt | EBI | MGI Sequence Detail 906 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 479
      cDNA 476
      Primer pair 1
      Other 2
      Antibodies 13

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1773, MGI:1913796, MGI:2147175, MGI:2147284
    References
    more
    • Summaries
      All 216
      Developmental Gene Expression 86
      Diseases 2
      Gene Ontology 28
      Phenotypes 48
    • Earliest
      J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
    • Latest
      J:381871 Berber M, et al., Rho/ROCK signaling and alpha-catenin mediate beta-catenin-driven hyperplasia in the adrenal cortex via adherens junctions. J Clin Invest. 2026 Mar 16;136(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory