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Ca1 Gene Detail
Summary
  • Symbol
    Ca1
  • Name
    carbonic anhydrase 1
  • Synonyms
    CA I, Car-1, Car1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88268
    NCBI Gene: 12346
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:14831274-14873425 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 3.18 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1592 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88268
 protein coding gene Chr3:14831274-14873428 (-)
129S1/SvImJ ENSMUSG00200018200
 protein coding gene Chr3:11573696-11615839 (-)
A/J ENSMUSG00195015416
 protein coding gene Chr3:11853511-11902546 (-)
AKR/J ENSMUSG00220008720
 protein coding gene Chr3:11910902-11953056 (-)
BALB/cJ ENSMUSG00180000968
 protein coding gene Chr3:11874411-11923445 (-)
C3H/HeJ ENSMUSG00175002990
 protein coding gene Chr3:11876750-11925782 (-)
C57BL/6NJ ENSMUSG00215001255
 protein coding gene Chr3:11872971-11915126 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005023622
 protein coding gene Chr3:11799439-11847023 (-)
CBA/J ENSMUSG00210001596
 protein coding gene Chr3:11845626-11894665 (-)
DBA/2J ENSMUSG00185000616
 protein coding gene Chr3:11855430-11897448 (-)
FVB/NJ ENSMUSG00205002277
 protein coding gene Chr3:11577131-11626158 (-)
JF1/MsJ ENSUMUG00000017944
 protein coding gene Chr3:11674584-11715883 (-)
LP/J ENSMUSG00230004338
 protein coding gene Chr3:13775613-13817760 (-)
NOD/ShiLtJ ENSMUSG00190002043
 protein coding gene Chr3:11955859-11998013 (-)
NZO/HlLtJ ENSMUSG00225000469
 protein coding gene Chr3:16359497-16401679 (-)
PWK/PhJ ENSLUMG00010002980
 protein coding gene Chr3:11816126-11857992 (-)
SPRET/EiJ ENSMSPG00010001809
 protein coding gene Chr3:11642259-11680998 (-)
WSB/EiJ ENSIUOG00005001365
 protein coding gene Chr3:11931032-11973152 (-)



Homology
more
  • Human Ortholog
    CA1, carbonic anhydrase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CA1, carbonic anhydrase 1
  • Synonyms
    CAB, CA-I, Car1, HEL-S-11
  • Links
    NCBI Gene ID: 759
    UniProt: P00915

  • Chr Location
    8q21.2; chr8:85327608-85379014 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ca1 mouse models; 7 with human CA1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
This locus controls electrophoretic variation in red blood cells. The a allele determines a slow migrating form in C57BL/6, C3H/He and other strains; the b allele determines a fast form in IS/Cam, WB/Re, SM, M. m. castaneus and M. m. molossinus. Homozygous null mice exhibit alkalization of the hippocampal hilus, leading to reduced miniature inhibitory postsynaptic current amplitude of granule cells and induction of depression-like and anxiety behaviors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    157
  • cDNA Data
    109
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12346 NCBI Gene Model | MGI Sequence Detail 42152 C57BL/6J ±  kb
    transcript NM_009799 RefSeq | MGI Sequence Detail 1196 C57BL/6  
    polypeptide P13634 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      Genomic 3
      cDNA 109
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1759, MGD-MRK-1762, MGI:2140006, MGI:8353808
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:5671 Davisson MT, et al., Genes on chromosome 3 of the mouse. J Hered. 1976 May-Jun;67(3):155-6
    • Latest
      J:364015 Chaverra M, et al., ELP1, the Gene Mutated in Familial Dysautonomia, Is Required for Normal Enteric Nervous System Development and Maintenance and for Gut Epithelium Homeostasis. J Neurosci. 2024 Sep 11;44(37)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory