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Cap1 Gene Detail
Summary
  • Symbol
    Cap1
  • Name
    cyclase associated actin cytoskeleton regulatory protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88262
    NCBI Gene: 12331
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:122752840-122779849 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 57.27 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    546 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88262
 protein coding gene Chr4:122752840-122779869 (-)
129S1/SvImJ ENSMUSG00200014409
 protein coding gene Chr4:116187967-116214550 (-)
A/J ENSMUSG00195031511
 protein coding gene Chr4:117518124-117544663 (-)
AKR/J ENSMUSG00220019974
 protein coding gene Chr4:116486587-116513596 (-)
BALB/cJ ENSMUSG00180040528
 protein coding gene Chr4:115157334-115183955 (-)
C3H/HeJ ENSMUSG00175024207
 protein coding gene Chr4:116170400-116197009 (-)
C57BL/6NJ ENSMUSG00215036977
 protein coding gene Chr4:117663644-117690650 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026425
 protein coding gene Chr4:112640722-112665734 (-)
CAST/EiJ ENSTCUG00005045290
 protein coding gene Chr4:117024653-117051304 (-)
CBA/J ENSMUSG00210051270
 protein coding gene Chr4:115776726-115803336 (-)
DBA/2J ENSMUSG00185040338
 protein coding gene Chr4:117331924-117358530 (-)
FVB/NJ ENSMUSG00205011702
 protein coding gene Chr4:115537666-115566074 (-)
JF1/MsJ ENSUMUG00000015385
 protein coding gene Chr4:117965168-117991986 (-)
LP/J ENSMUSG00230041644
 protein coding gene Chr4:121126088-121152670 (-)
NOD/ShiLtJ ENSMUSG00190041756
 protein coding gene Chr4:115531363-115559770 (-)
NZO/HlLtJ ENSMUSG00225015243
 protein coding gene Chr4:127033642-127060651 (-)
PWK/PhJ ENSLUMG00010046046
 protein coding gene Chr4:114986515-115013091 (-)
SPRET/EiJ ENSMSPG00010035086
 protein coding gene Chr4:117094148-117120713 (-)
WSB/EiJ ENSIUOG00005042058
 protein coding gene Chr4:115401459-115428032 (-)



Homology
more
  • Human Ortholog
    CAP1, cyclase associated actin cytoskeleton regulatory protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAP1, cyclase associated actin cytoskeleton regulatory protein 1
  • Synonyms
    CAP, CAP1-PEN
  • Links
    NCBI Gene ID: 10487
    UniProt: Q01518

  • Chr Location
    1p34.2; chr1:40039735-40072767 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    664
  • Tissues
    38
  • cDNA Data
    163
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028656 Ensembl Gene Model | MGI Sequence Detail 27010 C57BL/6J ±  kb
    transcript ENSMUST00000069533 Ensembl | MGI Sequence Detail 2620 Not Applicable  
    polypeptide ENSMUSP00000068260 Ensembl | MGI Sequence Detail 474 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000005006 adenylyl cyclase-associated protein 1
      (term hierarchy)
    • PDB
      6FM2, 6RSQ, 6RSW
    • InterPro Domains
      IPR001837 Adenylate cyclase-associated CAP
      IPR013912 Adenylate cyclase-associated CAP, C-terminal
      IPR036223 Adenylate cyclase-associated CAP, C-terminal superfamily
      IPR013992 Adenylate cyclase-associated CAP, N-terminal
      IPR036222 Adenylate cyclase-associated CAP, N-terminal domain superfamily
      IPR028417 CAP, conserved site, C-terminal
      IPR018106 CAP, conserved site, N-terminal
      IPR053950 CAP, N-terminal domain
      IPR006599 CARP motif
      IPR017901 C-CAP/cofactor C-like domain
      IPR016098 Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal
    • GlyGen
      P40124 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 164
      cDNA 163
      Primer pair 1
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1749
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:154091 Gogstad GO, et al., Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981 Sep 29;670(2):150-62
    • Latest
      J:387404 Ma H, et al., Cyclase-associated protein 1 facilitates actin-dependent mitochondrial fission in podocytes associated with diabetic nephropathy. Biochim Biophys Acta Mol Cell Res. 2026 May 31;:120166
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory