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Bmp6 Gene Detail
Summary
  • Symbol
    Bmp6
  • Name
    bone morphogenetic protein 6
  • Synonyms
    D13Wsu115e, Vgr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88182
    NCBI Gene: 12161
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr13:38529098-38684283 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 18.15 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3999 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88182
 protein coding gene Chr13:38529083-38684283 (+)
129S1/SvImJ ENSMUSG00200010408
 protein coding gene Chr13:35761139-35916415 (+)
A/J ENSMUSG00195032481
 protein coding gene Chr13:34844616-34999835 (+)
AKR/J ENSMUSG00220027631
 protein coding gene Chr13:34615472-34770680 (+)
BALB/cJ ENSMUSG00180007925
 protein coding gene Chr13:35150172-35305384 (+)
C3H/HeJ ENSMUSG00175012202
 protein coding gene Chr13:35102809-35257985 (+)
C57BL/6NJ ENSMUSG00215011453
 protein coding gene Chr13:35262917-35418150 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018442
 protein coding gene Chr13:33702743-33856475 (+)
CAST/EiJ ENSTCUG00005033734
 protein coding gene Chr13:35212421-35367691 (+)
CBA/J ENSMUSG00210011527
 protein coding gene Chr13:35110509-35265707 (+)
DBA/2J ENSMUSG00185031770
 protein coding gene Chr13:35928082-36083302 (+)
FVB/NJ ENSMUSG00205021688
 protein coding gene Chr13:34784069-34939376 (+)
JF1/MsJ ENSUMUG00000023955
 protein coding gene Chr13:35493935-35649109 (+)
LP/J ENSMUSG00230013199
 protein coding gene Chr13:45253389-45408578 (+)
NOD/ShiLtJ ENSMUSG00190011440
 protein coding gene Chr13:35324135-35479359 (+)
NZO/HlLtJ ENSMUSG00225034581
 protein coding gene Chr13:39037693-39192919 (+)
PWK/PhJ ENSLUMG00010026827
 protein coding gene Chr13:34315391-34469441 (+)
SPRET/EiJ ENSMSPG00010009676
 protein coding gene Chr13:34325922-34488172 (+)
WSB/EiJ ENSIUOG00005026030
 protein coding gene Chr13:34458171-34613521 (+)



Homology
more
  • Human Ortholog
    BMP6, bone morphogenetic protein 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMP6, bone morphogenetic protein 6
  • Synonyms
    IO, VGR, VGR1
  • Links
    NCBI Gene ID: 654
    UniProt: P22004

  • Chr Location
    6p24.3; chr6:7726049-7881728 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
One homozygous null mutant showed delayed ossification in the developing sternum while females of a second null mutant were smaller than normal in size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    107
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1077
  • Tissues
    303
  • cDNA Data
    18
  • Literature Summary
    109
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12161 NCBI Gene Model | MGI Sequence Detail 155186 C57BL/6J ±  kb
    transcript NM_007556 RefSeq | MGI Sequence Detail 3583 ZRU/MplStud  
    polypeptide P20722 UniProt | EBI | MGI Sequence Detail 510 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 1
      cDNA 22
      Primer pair 12
      Other 11
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15388, MGD-MRK-15390, MGD-MRK-1604, MGD-MRK-34025, MGI:106333
    References
    more
    • Summaries
      All 251
      Developmental Gene Expression 109
      Gene Ontology 23
      Phenotypes 37
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:364447 Fisher AL, et al., The hepcidin-ferroportin axis modulates liver endothelial cell BMP expression to influence iron homeostasis in mice. Blood. 2025 Feb 6;145(6):625-634
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory