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Defb25 Gene Detail
Summary
  • Symbol
    Defb25
  • Name
    defensin beta 25
  • Synonyms
    OTTMUSG00000015862
  • Feature Type
    protein coding gene
  • IDs
    MGI:3651158
    NCBI Gene: 654459
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152464276-152464973 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.41 cM
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3651158
 protein coding gene Chr2:152464274-152465002 (-)
129S1/SvImJ ENSMUSG00200026399
 protein coding gene Chr2:149363850-149364563 (-)
A/J ENSMUSG00195020183
 protein coding gene Chr2:149651314-149652011 (-)
AKR/J ENSMUSG00220038726
 protein coding gene Chr2:148973008-148973705 (-)
BALB/cJ ENSMUSG00180042474
 protein coding gene Chr2:149134560-149135281 (-)
C3H/HeJ ENSMUSG00175039400
 protein coding gene Chr2:149880791-149881514 (-)
C57BL/6NJ ENSMUSG00215019698
 protein coding gene Chr2:149307659-149308356 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024467
 protein coding gene Chr2:144505313-144506019 (-)
CAST/EiJ ENSTCUG00005038387
 protein coding gene Chr2:148233613-148234340 (-)
CBA/J ENSMUSG00210040636
 protein coding gene Chr2:149817309-149818030 (-)
DBA/2J ENSMUSG00185046450
 protein coding gene Chr2:149467848-149468565 (-)
FVB/NJ ENSMUSG00205019608
 protein coding gene Chr2:148564627-148565344 (-)
JF1/MsJ ENSUMUG00000021414
 protein coding gene Chr2:149139937-149140634 (-)
LP/J ENSMUSG00230033578
 protein coding gene Chr2:151116239-151116952 (-)
NOD/ShiLtJ ENSMUSG00190032449
 protein coding gene Chr2:149239324-149240021 (-)
NZO/HlLtJ ENSMUSG00225003430
 protein coding gene Chr2:159155989-159156706 (-)
PWK/PhJ ENSLUMG00010036387
 protein coding gene Chr2:149106594-149107291 (-)
SPRET/EiJ ENSMSPG00010027550
 protein coding gene Chr2:151834764-151835533 (-)
WSB/EiJ ENSIUOG00005046928
 protein coding gene Chr2:148971776-148972493 (-)



Homology
more
  • Human Ortholog
    DEFB124, defensin beta 124
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB124, defensin beta 124
  • Synonyms
    DEFB-24
  • Links
    NCBI Gene ID: 245937
    UniProt: Q8NES8

  • Chr Location
    20q11.21; chr20:31465471-31476757 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Defb25
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    9 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074678 Ensembl Gene Model | MGI Sequence Detail 698 C57BL/6J ±  kb
transcript ENSMUST00000099203 Ensembl | MGI Sequence Detail 293 Not Applicable  
polypeptide ENSMUSP00000096809 Ensembl | MGI Sequence Detail 71 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 1
References
more
  • Summaries
    All 24
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory