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Defb18 Gene Detail
Summary
  • Symbol
    Defb18
  • Name
    defensin beta 18
  • Synonyms
    EG654460
  • Feature Type
    protein coding gene
  • IDs
    MGI:3648148
    NCBI Gene: 654460
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:18306697-18307667 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 5.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3648148
 protein coding gene Chr1:18306626-18307700 (-)
129S1/SvImJ ENSMUSG00200018443
 protein coding gene Chr1:15712217-15713187 (-)
A/J ENSMUSG00195027345
 protein coding gene Chr1:15480965-15481935 (-)
AKR/J ENSMUSG00220007831
 protein coding gene Chr1:15521479-15522449 (-)
BALB/cJ ENSMUSG00180023950
 protein coding gene Chr1:15547321-15548291 (-)
C3H/HeJ ENSMUSG00175000085
 protein coding gene Chr1:15473343-15474313 (-)
C57BL/6NJ ENSMUSG00215008129
 protein coding gene Chr1:15538839-15539809 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013977
 protein coding gene Chr1:14029748-14030715 (-)
CAST/EiJ ENSTCUG00005021265
 protein coding gene Chr1:15856637-15857608 (-)
CBA/J ENSMUSG00210002764
 protein coding gene Chr1:15350499-15351469 (-)
DBA/2J ENSMUSG00185003843
 protein coding gene Chr1:16388367-16389337 (-)
FVB/NJ ENSMUSG00205012715
 protein coding gene Chr1:15567867-15568837 (-)
JF1/MsJ ENSUMUG00000012392
 protein coding gene Chr1:15635205-15636168 (-)
LP/J ENSMUSG00230015556
 protein coding gene Chr1:16413449-16414419 (-)
NOD/ShiLtJ ENSMUSG00190026154
 protein coding gene Chr1:15459892-15460862 (-)
NZO/HlLtJ ENSMUSG00225004517
 protein coding gene Chr1:19767804-19768774 (-)
PWK/PhJ ENSLUMG00010021388
 protein coding gene Chr1:15274309-15275279 (-)
SPRET/EiJ ENSMSPG00010025609
 protein coding gene Chr1:16066320-16067307 (-)
WSB/EiJ ENSIUOG00005011402
 protein coding gene Chr1:15448870-15449840 (-)



Homology
more
  • Human Ortholog
    DEFB113, defensin beta 113
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB113, defensin beta 113
  • Synonyms
    DEFB-13
  • Links
    NCBI Gene ID: 245927
    UniProt: Q30KQ7

  • Chr Location
    6p12.3; chr6:49968677-49969625 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000073735 Ensembl Gene Model | MGI Sequence Detail 971 C57BL/6J ±  kb
transcript ENSMUST00000097818 Ensembl | MGI Sequence Detail 258 Not Applicable  
polypeptide ENSMUSP00000095427 Ensembl | MGI Sequence Detail 85 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 17
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:101568 Patil AA, et al., Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Physiol Genomics. 2005 Sep 21;23(1):5-17
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory