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Siglec15 Gene Detail
Summary
  • Symbol
    Siglec15
  • Name
    sialic acid binding Ig-like lectin 15
  • Synonyms
    Cd33l3, EG620235
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646642
    NCBI Gene: 620235
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:78086829-78100610 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 52.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    506 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646642
 protein coding gene Chr18:78085708-78100656 (-)
129S1/SvImJ ENSMUSG00200026138
 protein coding gene Chr18:75324030-75337692 (-)
A/J ENSMUSG00195004798
 protein coding gene Chr18:75374840-75388631 (-)
AKR/J ENSMUSG00220017210
 protein coding gene Chr18:75316547-75330337 (-)
BALB/cJ ENSMUSG00180012736
 protein coding gene Chr18:75945267-75959050 (-)
C3H/HeJ ENSMUSG00175011494
 protein coding gene Chr18:75496948-75510738 (-)
C57BL/6NJ ENSMUSG00215023913
 protein coding gene Chr18:74853148-74866937 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022425
 protein coding gene Chr18:74336853-74350639 (-)
CAST/EiJ ENSTCUG00005027490
 protein coding gene Chr18:74396633-74410401 (-)
CBA/J ENSMUSG00210033770
 protein coding gene Chr18:75454223-75468006 (-)
DBA/2J ENSMUSG00185010582
 protein coding gene Chr18:75359816-75373589 (-)
FVB/NJ ENSMUSG00205012395
 protein coding gene Chr18:74979528-74993704 (-)
JF1/MsJ ENSUMUG00000032745
 protein coding gene Chr18:75284950-75299022 (-)
LP/J ENSMUSG00230011453
 protein coding gene Chr18:77430434-77444092 (-)
NOD/ShiLtJ ENSMUSG00190021677
 protein coding gene Chr18:75117429-75131218 (-)
NZO/HlLtJ ENSMUSG00225033634
 protein coding gene Chr18:77291753-77305542 (-)
PWK/PhJ ENSLUMG00010006592
 protein coding gene Chr18:75681143-75695201 (-)
SPRET/EiJ ENSMSPG00010007942
 protein coding gene Chr18:75950695-75964683 (-)
WSB/EiJ ENSIUOG00005007174
 protein coding gene Chr18:74847702-74861481 (-)



Homology
more
  • Human Ortholog
    SIGLEC15, sialic acid binding Ig like lectin 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIGLEC15, sialic acid binding Ig like lectin 15
  • Synonyms
    CD33L3, HsT1361, SIGLEC-15
  • Links
    NCBI Gene ID: 284266
    UniProt: Q6ZMC9

  • Chr Location
    18q12.3; chr18:45825675-45844094 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit impaired osteoclast differentiation and function and mild osteopetrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    617
  • Tissues
    20
  • cDNA Data
    5
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000091055 Ensembl Gene Model | MGI Sequence Detail 13782 C57BL/6J ±  kb
    transcript ENSMUST00000170760 Ensembl | MGI Sequence Detail 1156 Not Applicable  
    polypeptide ENSMUSP00000126901 Ensembl | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR003599 Immunoglobulin domain subtype
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR013106 Immunoglobulin V-set domain
      IPR042836 Sialic acid-binding Ig-like lectin 15
    • GlyGen
      A7E1W8 1 site
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 10
    • Earliest
      J:193006 Ishida-Kitagawa N, et al., Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12). J Biol Chem. 2012 May 18;287(21):17493-502
    • Latest
      J:381486 Dou C, et al., Estradiol regulates osteoclast sialylation via ST3Gal1 in postmenopausal osteoporosis. Bone Res. 2026 Feb 12;14(1):22
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory