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Krtap27-1 Gene Detail
Summary
  • Symbol
    Krtap27-1
  • Name
    keratin associated protein 27-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646229
    NCBI Gene: 239933
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:88467914-88468559 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 51.39 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646229
 protein coding gene Chr16:88467914-88468612 (-)
129S1/SvImJ ENSMUSG00200036690
 protein coding gene Chr16:85343839-85344484 (-)
A/J ENSMUSG00195027660
 protein coding gene Chr16:85146968-85147613 (-)
AKR/J ENSMUSG00220015284
 protein coding gene Chr16:85338749-85339394 (-)
BALB/cJ ENSMUSG00180014958
 protein coding gene Chr16:85220261-85220906 (-)
C3H/HeJ ENSMUSG00175015937
 protein coding gene Chr16:85558484-85559129 (-)
C57BL/6NJ ENSMUSG00215022168
 protein coding gene Chr16:85348880-85349525 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020909
 protein coding gene Chr16:83162257-83162902 (-)
CAST/EiJ ENSTCUG00005018193
 protein coding gene Chr16:84916059-84916701 (-)
CBA/J ENSMUSG00210036724
 protein coding gene Chr16:85449007-85449652 (-)
DBA/2J ENSMUSG00185030733
 protein coding gene Chr16:85400301-85400946 (-)
FVB/NJ ENSMUSG00205016236
 protein coding gene Chr16:85197087-85197732 (-)
JF1/MsJ ENSUMUG00000025212
 protein coding gene Chr16:85552585-85553227 (-)
LP/J ENSMUSG00230033419
 protein coding gene Chr16:87903545-87904190 (-)
NOD/ShiLtJ ENSMUSG00190020934
 protein coding gene Chr16:85374718-85375363 (-)
NZO/HlLtJ ENSMUSG00225029525
 protein coding gene Chr16:91088421-91089066 (-)
PWK/PhJ ENSLUMG00010013618
 protein coding gene Chr16:85197110-85197755 (-)
SPRET/EiJ ENSMSPG00010028210
 protein coding gene Chr16:86334519-86335161 (-)
WSB/EiJ ENSIUOG00005018121
 protein coding gene Chr16:85334965-85335610 (-)



Homology
more
  • Human Ortholog
    KRTAP27-1, keratin associated protein 27-1
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRTAP27-1, keratin associated protein 27-1
  • Links
    NCBI Gene ID: 643812
    UniProt: Q3LI81

  • Chr Location
    21q22.11; chr21:30337013-30337694 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000090515 Ensembl Gene Model | MGI Sequence Detail 646 C57BL/6J ±  kb
transcript ENSMUST00000165580 Ensembl | MGI Sequence Detail 646 Not Applicable  
polypeptide ENSMUSP00000129289 Ensembl | MGI Sequence Detail 202 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR007951 Keratin-associated protein, PMG type
    IPR007659 Keratin, high-sulphur matrix protein
References
more
  • Summaries
    All 19
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:117029 Davisson M, et al., Impact of trisomy on fertility and meiosis in male mice. Hum Reprod. 2007 Feb;22(2):468-76
  • Latest
    J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory