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Lsmem2 Gene Detail
Summary
  • Symbol
    Lsmem2
  • Name
    leucine-rich single-pass membrane protein 2
  • Synonyms
    BY080835
  • Feature Type
    protein coding gene
  • IDs
    MGI:3612240
    NCBI Gene: 434436
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107469829-107474274 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.28 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3612240
 protein coding gene Chr9:107469825-107475189 (-)
129S1/SvImJ ENSMUSG00200039612
 protein coding gene Chr9:104664898-104669558 (-)
A/J ENSMUSG00195039321
 protein coding gene Chr9:103883666-103888327 (-)
AKR/J ENSMUSG00220024028
 protein coding gene Chr9:104273553-104278213 (-)
BALB/cJ ENSMUSG00180033643
 protein coding gene Chr9:104200121-104204782 (-)
C3H/HeJ ENSMUSG00175042088
 protein coding gene Chr9:104542432-104547092 (-)
C57BL/6NJ ENSMUSG00215027777
 protein coding gene Chr9:104520183-104524628 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0006830
 lincRNA gene Chr9:102920207-102923437 (-)
CAST/EiJ ENSTCUG00005027520
 protein coding gene Chr9:104292864-104297335 (-)
CBA/J ENSMUSG00210032469
 protein coding gene Chr9:104390327-104394772 (-)
DBA/2J ENSMUSG00185035375
 protein coding gene Chr9:104555153-104559598 (-)
FVB/NJ ENSMUSG00205049426
 protein coding gene Chr9:104553143-104557805 (-)
JF1/MsJ ENSUMUG00000054066
 protein coding gene Chr9:104379318-104383763 (-)
LP/J ENSMUSG00230049995
 protein coding gene Chr9:104693832-104698492 (-)
NOD/ShiLtJ ENSMUSG00190047146
 protein coding gene Chr9:104190328-104194988 (-)
NZO/HlLtJ ENSMUSG00225024414
 protein coding gene Chr9:104927948-104932608 (-)
PWK/PhJ ENSLUMG00010031600
 protein coding gene Chr9:104337924-104342371 (-)
SPRET/EiJ ENSMSPG00010034115
 protein coding gene Chr9:106167631-106172059 (-)
WSB/EiJ ENSIUOG00005041606
 protein coding gene Chr9:103636928-103641389 (-)



Homology
more
  • Human Ortholog
    LSMEM2, leucine rich single-pass membrane protein 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LSMEM2, leucine rich single-pass membrane protein 2
  • Synonyms
    C3orf45
  • Links
    NCBI Gene ID: 132228
    UniProt: Q8N112

  • Chr Location
    chr3:50277907-50288116 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Homozygotes for a knock-out allele are viable and fertile and do not exhibit muscle abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000103409 Ensembl Gene Model | MGI Sequence Detail 4446 C57BL/6J ±  kb
transcript ENSMUST00000238519 Ensembl | MGI Sequence Detail 1424 Not Applicable  
polypeptide ENSMUSP00000158647 Ensembl | MGI Sequence Detail 150 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR031674 Protein of unknown function DUF4714
  • GlyGen
    A0A571BE98 1 site
References
more
  • Summaries
    All 17
    Gene Ontology 1
    Phenotypes 6
  • Earliest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
  • Latest
    J:380940 Elrefaei E, et al., LSMEM2, Localized at the Neuromuscular Junction, Modulates Mitochondrial Integration in Skeletal Muscles. FASEB J. 2025 Jun 30;39(12):e70609
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory