About   Help   FAQ
Firrm Gene Detail
Summary
  • Symbol
    Firrm
  • Name
    FIGNL1 interacting regulator of recombination and mitosis
  • Synonyms
    BC055324, Flip
  • Feature Type
    protein coding gene
  • IDs
    MGI:3590554
    NCBI Gene: 381306
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:163773562-163822365 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 71.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1067 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3590554
 protein coding gene Chr1:163773409-163822377 (-)
129S1/SvImJ ENSMUSG00200006466
 protein coding gene Chr1:161243894-161292869 (-)
A/J ENSMUSG00195019627
 protein coding gene Chr1:160584131-160633104 (-)
AKR/J ENSMUSG00220013798
 protein coding gene Chr1:160362831-160413776 (-)
BALB/cJ ENSMUSG00180035449
 protein coding gene Chr1:160826046-160875021 (-)
C3H/HeJ ENSMUSG00175042001
 protein coding gene Chr1:160916725-160965681 (-)
C57BL/6NJ ENSMUSG00215037000
 protein coding gene Chr1:160793914-160842882 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014787
 protein coding gene Chr1:154426597-154478706 (-)
CAST/EiJ ENSTCUG00005019225
 protein coding gene Chr1:159380821-159430066 (-)
CBA/J ENSMUSG00210020937
 protein coding gene Chr1:160789334-160838299 (-)
DBA/2J ENSMUSG00185011448
 protein coding gene Chr1:165034790-165083880 (-)
FVB/NJ ENSMUSG00205008695
 protein coding gene Chr1:159867944-159917208 (-)
JF1/MsJ ENSUMUG00000005325
 protein coding gene Chr1:164185009-164234077 (-)
LP/J ENSMUSG00230022031
 protein coding gene Chr1:164654327-164703302 (-)
NOD/ShiLtJ ENSMUSG00190037313
 protein coding gene Chr1:160630468-160679744 (-)
NZO/HlLtJ ENSMUSG00225003514
 protein coding gene Chr1:168247625-168296902 (-)
PWK/PhJ ENSLUMG00010040321
 protein coding gene Chr1:159574715-159623559 (-)
SPRET/EiJ ENSMSPG00010040220
 protein coding gene Chr1:163057985-163106870 (-)
WSB/EiJ ENSIUOG00005013831
 protein coding gene Chr1:160134090-160183385 (-)



Homology
more
  • Human Ortholog
    FIRRM, FIGNL1 interacting regulator of recombination and mitosis
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FIRRM, FIGNL1 interacting regulator of recombination and mitosis
  • Synonyms
    Apolo1, C1orf112, FLIP, MEICA1
  • Links
    NCBI Gene ID: 55732
    UniProt: Q9NSG2

  • Chr Location
    1q24.2; chr1:169662007-169855456 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 4 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are embryonic lethal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    2
  • cDNA Data
    52
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041406 Ensembl Gene Model | MGI Sequence Detail 48804 C57BL/6J ±  kb
    transcript ENSMUST00000097493 Ensembl | MGI Sequence Detail 3217 Not Applicable  
    polypeptide ENSMUSP00000095101 Ensembl | MGI Sequence Detail 927 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:7437648
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
    • Latest
      J:361285 Cao H, et al., Extensive homologous recombination safeguards oocyte genome integrity in mammals. Nucleic Acids Res. 2025 Jan 11;53(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory