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C1qtnf9 Gene Detail
Summary
  • Symbol
    C1qtnf9
  • Name
    C1q and tumor necrosis factor related protein 9
  • Synonyms
    9130217G22Rik, CTRP9
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045252
    NCBI Gene: 239126
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:61005583-61018318 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 31.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    498 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045252
 protein coding gene Chr14:61005583-61018318 (+)
129S1/SvImJ ENSMUSG00200041045
 protein coding gene Chr14:49598699-49611443 (+)
A/J ENSMUSG00195029394
 protein coding gene Chr14:49780842-49793589 (+)
AKR/J ENSMUSG00220028212
 protein coding gene Chr14:49128044-49140801 (+)
BALB/cJ ENSMUSG00180051383
 protein coding gene Chr14:49402729-49415479 (+)
C3H/HeJ ENSMUSG00175044380
 protein coding gene Chr14:51141250-51153968 (+)
C57BL/6NJ ENSMUSG00215048623
 protein coding gene Chr14:49332053-49344786 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019377
 protein coding gene Chr14:51943137-51956873 (+)
CAST/EiJ ENSTCUG00005048804
 protein coding gene Chr14:51067292-51080060 (+)
CBA/J ENSMUSG00210044316
 protein coding gene Chr14:49768937-49781662 (+)
DBA/2J ENSMUSG00185029647
 protein coding gene Chr14:54938958-54951678 (+)
FVB/NJ ENSMUSG00205040555
 protein coding gene Chr14:49265746-49278342 (+)
JF1/MsJ ENSUMUG00000044013
 protein coding gene Chr14:66133790-66146539 (+)
LP/J ENSMUSG00230035468
 protein coding gene Chr14:66961988-66974725 (+)
NOD/ShiLtJ ENSMUSG00190046066
 protein coding gene Chr14:49564925-49577661 (+)
NZO/HlLtJ ENSMUSG00225045735
 protein coding gene Chr14:57306499-57319235 (+)
PWK/PhJ ENSLUMG00010042498
 protein coding gene Chr14:49017760-49030496 (+)
SPRET/EiJ ENSMSPG00010030719
 protein coding gene Chr14:52443217-52455948 (+)
WSB/EiJ ENSIUOG00005038602
 protein coding gene Chr14:49000208-49012962 (+)



Homology
more
  • Human Ortholog
    C1QTNF9, C1q and TNF related 9
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C1QTNF9, C1q and TNF related 9
  • Synonyms
    AQL1, C1QTNF9A, CTRP9
  • Links
    NCBI Gene ID: 338872
    UniProt: P0C862

  • Chr Location
    13q12.12; chr13:24307166-24322535 (+)  GRCh38
  • Human Ortholog
    C1QTNF9B, C1q and TNF related 9B
  • Synonyms
    CTRP9B
  • Links
    NCBI Gene ID: 387911
    UniProt: B2RNN3

  • Chr Location
    13q12.12; chr13:23891099-23897502 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased caloric intake, increased percent body fat/body weight, obesity, insulin resistance, and hepatic steatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    627
  • Tissues
    23
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 239126 NCBI Gene Model | MGI Sequence Detail 12736 C57BL/6J ±  kb
    transcript NM_183175 RefSeq | MGI Sequence Detail 1903 C57BL/6  
    polypeptide Q4ZJN1 UniProt | EBI | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR001073 C1q domain
      IPR050392 Collagen/C1q domain-containing
      IPR008160 Collagen triple helix repeat
      IPR008983 Tumour necrosis factor-like domain superfamily
    • GlyGen
      Q4ZJN1 4 sites
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:143939 Wong GW, et al., Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J. 2008 Dec 1;416(2):161-77
    • Latest
      J:378075 Fan H, et al., Partial embryo loss caused by disruption of the placental hormone CTRP6 coincides with dNK cell abnormalities during pregnancy. iScience. 2026 Jan 16;29(1):114434
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory