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Dlgap3 Gene Detail
Summary
  • Symbol
    Dlgap3
  • Name
    DLG associated protein 3
  • Synonyms
    DAP3, Prpl8, PSD-95/SAP90-binding protein 3, SAP90/PSD 95 associated protein 3, Sapap3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039563
    NCBI Gene: 242667
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:127062997-127130815 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 61.33 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1624 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039563
 protein coding gene Chr4:127062090-127130815 (+)
129S1/SvImJ ENSMUSG00200011619
 protein coding gene Chr4:120502293-120570117 (+)
A/J ENSMUSG00195027292
 protein coding gene Chr4:121838727-121906611 (+)
AKR/J ENSMUSG00220020562
 protein coding gene Chr4:120818859-120886693 (+)
BALB/cJ ENSMUSG00180043744
 protein coding gene Chr4:119472523-119540400 (+)
C3H/HeJ ENSMUSG00175025107
 protein coding gene Chr4:120485200-120553077 (+)
C57BL/6NJ ENSMUSG00215050240
 protein coding gene Chr4:121982444-122050283 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026491
 protein coding gene Chr4:116946264-117013924 (+)
CAST/EiJ ENSTCUG00005041164
 protein coding gene Chr4:121368374-121435955 (+)
CBA/J ENSMUSG00210051299
 protein coding gene Chr4:120114083-120181952 (+)
DBA/2J ENSMUSG00185043269
 protein coding gene Chr4:121646725-121714587 (+)
FVB/NJ ENSMUSG00205016593
 protein coding gene Chr4:119858678-119926777 (+)
JF1/MsJ ENSUMUG00000012427
 protein coding gene Chr4:122281250-122349119 (+)
LP/J ENSMUSG00230029872
 protein coding gene Chr4:125439931-125507744 (+)
NOD/ShiLtJ ENSMUSG00190033104
 protein coding gene Chr4:119859082-119926739 (+)
NZO/HlLtJ ENSMUSG00225015310
 protein coding gene Chr4:131346646-131414467 (+)
PWK/PhJ ENSLUMG00010045079
 protein coding gene Chr4:119316888-119384648 (+)
SPRET/EiJ ENSMSPG00010034815
 protein coding gene Chr4:121392980-121460281 (+)
WSB/EiJ ENSIUOG00005037826
 protein coding gene Chr4:119717516-119785610 (+)



Homology
more
  • Human Ortholog
    DLGAP3, DLG associated protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLGAP3, DLG associated protein 3
  • Synonyms
    DAP3, SAPAP3, SPAPA3
  • Links
    NCBI Gene ID: 58512
    UniProt: O95886

  • Chr Location
    1p34.3; chr1:34865436-34929650 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit skin lesions associated with excessive grooming, increased anxiety-related behaviors, altered synaptic transmission and abnormal sleep patterns.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    1
  • cDNA Data
    28
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042388 Ensembl Gene Model | MGI Sequence Detail 67819 C57BL/6J ±  kb
    transcript ENSMUST00000046659 Ensembl | MGI Sequence Detail 3884 Not Applicable  
    polypeptide ENSMUSP00000039724 Ensembl | MGI Sequence Detail 977 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:892992
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 50
    • Earliest
      J:39869 Yehiely F, et al., Identification of candidate proteins binding to prion protein. Neurobiol Dis. 1997;3(4):339-55
    • Latest
      J:389864 Murata K, et al., A novel miniTurbo knock-in mouse reveals a protein interaction network of USP46 in the brain. Exp Anim. 2026 Jan 1;75(1):63-72
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory