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Defb42 Gene Detail
Summary
  • Symbol
    Defb42
  • Name
    defensin beta 42
  • Feature Type
    protein coding gene
  • IDs
    MGI:3033850
    NCBI Gene: 619548
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:63284445-63286052 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.24 cM, cytoband C3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3033850
 protein coding gene Chr14:63284440-63295598 (+)
129S1/SvImJ ENSMUSG00200027788
 protein coding gene Chr14:51885459-51887078 (+)
A/J ENSMUSG00195028709
 protein coding gene Chr14:52066249-52067868 (+)
AKR/J ENSMUSG00220026818
 protein coding gene Chr14:51413654-51415273 (+)
BALB/cJ ENSMUSG00180032997
 protein coding gene Chr14:51688143-51689762 (+)
C3H/HeJ ENSMUSG00175034548
 protein coding gene Chr14:53421286-53422905 (+)
C57BL/6NJ ENSMUSG00215048532
 protein coding gene Chr14:51611706-51613325 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019399
 protein coding gene Chr14:54202550-54214395 (+)
CAST/EiJ ENSTCUG00005033755
 protein coding gene Chr14:53351683-53353307 (+)
CBA/J ENSMUSG00210033737
 protein coding gene Chr14:52054158-52055781 (+)
DBA/2J ENSMUSG00185031231
 protein coding gene Chr14:57219093-57220712 (+)
FVB/NJ ENSMUSG00205033330
 protein coding gene Chr14:51571663-51573282 (+)
JF1/MsJ ENSUMUG00000043947
 protein coding gene Chr14:68413469-68415124 (+)
LP/J ENSMUSG00230034293
 protein coding gene Chr14:69248666-69250285 (+)
NOD/ShiLtJ ENSMUSG00190031913
 protein coding gene Chr14:51848881-51850500 (+)
NZO/HlLtJ ENSMUSG00225044841
 protein coding gene Chr14:59591043-59592662 (+)
PWK/PhJ ENSLUMG00010046762
 protein coding gene Chr14:51299005-51300640 (+)
SPRET/EiJ ENSMSPG00010030572
 protein coding gene Chr14:54787513-54789158 (+)
WSB/EiJ ENSIUOG00005036349
 protein coding gene Chr14:51295114-51296737 (+)



Homology
more
  • Human Ortholog
    DEFB136, defensin beta 136
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB136, defensin beta 136
  • Synonyms
    DEFB137
  • Links
    NCBI Gene ID: 613210
    UniProt: Q30KP8

  • Chr Location
    8p23.1; chr8:11973937-11974599 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Genomic Mutations
    1 involving Defb42
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    6 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    2
  • cDNA Data
    6
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 619548 NCBI Gene Model | MGI Sequence Detail 1608 C57BL/6J ±  kb
transcript NM_001412580 RefSeq | MGI Sequence Detail 710 C57BL/6  
polypeptide Q8BVB5 UniProt | EBI | MGI Sequence Detail 75 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:100553 Jalkanen J, et al., Discovery and characterization of new epididymis-specific beta-defensins in mice. Biochim Biophys Acta. 2005 Jul 25;1730(1):22-30
  • Latest
    J:156769 Amid C, et al., Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome. BMC Genomics. 2009;10:606
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory