C1ql2 MGI Mouse Gene Detail - MGI:3032521 - complement component 1, q subcomponent-like 2

Symbol

C1ql2
Name

complement component 1, q subcomponent-like 2
Synonyms

CTRP10

Feature Type

protein coding gene
IDs

MGI:3032521
NCBI Gene: 226359
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:120268312-120270903 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 52.68 cM
Mapping Data

1 experiment

SNPs within 2kb

104 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3032521	protein coding gene	Chr1:120268312-120270903 (+)
129S1/SvImJ	ENSMUSG00200001686	protein coding gene	Chr1:117756032-117758622 (+)
A/J	ENSMUSG00195004262	protein coding gene	Chr1:116996894-116999484 (+)
AKR/J	ENSMUSG00220024933	protein coding gene	Chr1:116812646-116815236 (+)
BALB/cJ	ENSMUSG00180012366	protein coding gene	Chr1:117406081-117408671 (+)
C3H/HeJ	ENSMUSG00175019242	protein coding gene	Chr1:117227938-117230528 (+)
C57BL/6NJ	ENSMUSG00215009634	protein coding gene	Chr1:117175472-117178063 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014523	protein coding gene	Chr1:112361456-112364030 (+)
CAST/EiJ	ENSTCUG00005005915	protein coding gene	Chr1:116160816-116163403 (+)
CBA/J	ENSMUSG00210001234	protein coding gene	Chr1:117057305-117059895 (+)
DBA/2J	ENSMUSG00185013271	protein coding gene	Chr1:121505661-121508251 (+)
FVB/NJ	ENSMUSG00205011711	protein coding gene	Chr1:116559703-116562293 (+)
JF1/MsJ	ENSUMUG00000027137	protein coding gene	Chr1:120594434-120597021 (+)
LP/J	ENSMUSG00230008456	protein coding gene	Chr1:120933808-120936398 (+)
NOD/ShiLtJ	ENSMUSG00190006083	protein coding gene	Chr1:117042485-117045075 (+)
NZO/HlLtJ	ENSMUSG00225004357	protein coding gene	Chr1:124728500-124731090 (+)
PWK/PhJ	ENSLUMG00010014028	protein coding gene	Chr1:116192962-116195548 (+)
SPRET/EiJ	ENSMSPG00010015857	protein coding gene	Chr1:118821023-118823619 (+)
WSB/EiJ	ENSIUOG00005002740	protein coding gene	Chr1:116900783-116903374 (+)

Human Ortholog

C1QL2, complement C1q like 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C1QL2, complement C1q like 2
Synonyms

C1QTNF10, CTRP10
Links

HGNC:24181

NCBI Gene ID: 165257

UniProt: Q7Z5L3
Chr Location

2q14.2; chr2:119156243-119158751 (-) GRCh38

MGI Vertebrate Homology

C1ql2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: C1QL2
Gene Tree

C1ql2

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

7
Radiation induced

1
Targeted

1
Genomic Mutations

3 involving C1ql2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Female mice homozygous for a knock-out allele show decreased mitochondrial respiration in the motor cortex and pronounced deficits in gross motor coordination and fine motor skills, with male mice exhibiting milder phenotypes.

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All GO Annotations

24
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

639
Tissues

30
cDNA Data

9
Literature Summary

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS15233.1

Ensembl

ENSMUSG00000036907 (Evidence)
NCBI Gene

226359

			Length	Strain/Species	Flank
genomic	226359	NCBI Gene Model \| MGI Sequence Detail	2592	C57BL/6J	± kb
transcript	NM_207233	RefSeq \| MGI Sequence Detail	2070	Not Specified
polypeptide	Q8CFR0	UniProt \| EBI \| MGI Sequence Detail	287	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004880 complement C1q-like protein 2

(term hierarchy)
PDB

4QPY
InterPro Domains

IPR001073 C1q domain

IPR050822 Cerebellin Synaptic Organizer

IPR008983 Tumour necrosis factor-like domain superfamily

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All nucleic 12

cDNA 9

Primer pair 2

Other 1

Microarray probesets 2

Summaries

All 49

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 18
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:387475 Hijazi S, et al., Diversity and sensorimotor specialization of head direction cells in the mouse thalamus. Curr Biol. 2026 Jun 10;

TSS for C1ql2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8402	Chr1:120268299-120268310 (+)	-7 bp
Tssr8403	Chr1:120268335-120268375 (+)	43 bp
Tssr8404	Chr1:120268385-120268394 (+)	78 bp
Tssr8405	Chr1:120268490-120268499 (+)	183 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24