About   Help   FAQ
Fbxo10 Gene Detail
Summary
  • Symbol
    Fbxo10
  • Name
    F-box protein 10
  • Synonyms
    FBX10, LOC269529
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686937
    NCBI Gene: 269529
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:45034248-45084555 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1338 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686937
 protein coding gene Chr4:45034247-45084604 (-)
129S1/SvImJ ENSMUSG00200002756
 protein coding gene Chr4:41082535-41132907 (-)
A/J ENSMUSG00195005554
 protein coding gene Chr4:41546667-41597041 (-)
AKR/J ENSMUSG00220002724
 protein coding gene Chr4:41232706-41283078 (-)
BALB/cJ ENSMUSG00180026618
 protein coding gene Chr4:41133347-41183718 (-)
C3H/HeJ ENSMUSG00175021128
 protein coding gene Chr4:41277587-41327960 (-)
C57BL/6NJ ENSMUSG00215018082
 protein coding gene Chr4:41055976-41106350 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025968
 protein coding gene Chr4:39100958-39150634 (-)
CAST/EiJ ENSTCUG00005036417
 protein coding gene Chr4:41318613-41368633 (-)
CBA/J ENSMUSG00210019280
 protein coding gene Chr4:40969404-41019777 (-)
DBA/2J ENSMUSG00185030152
 protein coding gene Chr4:41332825-41383197 (-)
FVB/NJ ENSMUSG00205018339
 protein coding gene Chr4:40601683-40652059 (-)
JF1/MsJ ENSUMUG00000032691
 protein coding gene Chr4:41561586-41611766 (-)
LP/J ENSMUSG00230041692
 protein coding gene Chr4:44883637-44934008 (-)
NOD/ShiLtJ ENSMUSG00190022583
 protein coding gene Chr4:41190930-41241301 (-)
NZO/HlLtJ ENSMUSG00225006529
 protein coding gene Chr4:49477952-49528324 (-)
PWK/PhJ ENSLUMG00010011737
 protein coding gene Chr4:40563904-40615199 (-)
SPRET/EiJ ENSMSPG00010008674
 protein coding gene Chr4:41491457-41540864 (-)
WSB/EiJ ENSIUOG00005004053
 protein coding gene Chr4:40941045-40991352 (-)



Homology
more
  • Human Ortholog
    FBXO10, F-box protein 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXO10, F-box protein 10
  • Synonyms
    FBX10, PRMT11
  • Links
    NCBI Gene ID: 26267
    UniProt: Q9UK96

  • Chr Location
    9p13.2; chr9:37510892-37576380 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    598
  • Tissues
    1
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269529 NCBI Gene Model | MGI Sequence Detail 50308 C57BL/6J ±  kb
    transcript NM_001378822 RefSeq | MGI Sequence Detail 5104 C57BL/6  
    polypeptide Q7TQF2 UniProt | EBI | MGI Sequence Detail 950 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685480
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:94083 Klarlund JK, et al., Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1. J Biol Chem. 2001 Oct 26;276(43):40065-70
    • Latest
      J:367461 Hu J, et al., F-box only protein 10 protects against kidney tubulointerstitial fibrosis by inhibiting ACSL4-mediated lipid peroxidation and ferroptosis. Cell Signal. 2025 Aug;132:111841
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory