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Usf3 Gene Detail
Summary
  • Symbol
    Usf3
  • Name
    upstream transcription factor family member 3
  • Synonyms
    5530400K22Rik, Gm608, LOC207806, LOC385650
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685454
    NCBI Gene: 207806
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:43993609-44047828 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 28.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1251 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685454
 protein coding gene Chr16:43993566-44047828 (+)
129S1/SvImJ ENSMUSG00200021018
 protein coding gene Chr16:40891921-40946164 (+)
A/J ENSMUSG00195003221
 protein coding gene Chr16:40463320-40517569 (+)
AKR/J ENSMUSG00220021966
 protein coding gene Chr16:40798707-40852968 (+)
BALB/cJ ENSMUSG00180025550
 protein coding gene Chr16:40669809-40724048 (+)
C3H/HeJ ENSMUSG00175023818
 protein coding gene Chr16:40947572-41001830 (+)
C57BL/6NJ ENSMUSG00215006931
 protein coding gene Chr16:40773615-40827844 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020764
 protein coding gene Chr16:41026334-41079379 (+)
CAST/EiJ ENSTCUG00005012517
 protein coding gene Chr16:41197940-41252611 (+)
CBA/J ENSMUSG00210016630
 protein coding gene Chr16:40970349-41024609 (+)
DBA/2J ENSMUSG00185010717
 protein coding gene Chr16:40849552-40903786 (+)
FVB/NJ ENSMUSG00205010875
 protein coding gene Chr16:40802016-40856249 (+)
JF1/MsJ ENSUMUG00000018713
 protein coding gene Chr16:41081788-41136213 (+)
LP/J ENSMUSG00230024982
 protein coding gene Chr16:43445137-43499381 (+)
NOD/ShiLtJ ENSMUSG00190017568
 protein coding gene Chr16:40979307-41033540 (+)
NZO/HlLtJ ENSMUSG00225028679
 protein coding gene Chr16:46531178-46585431 (+)
PWK/PhJ ENSLUMG00010025763
 protein coding gene Chr16:40979448-41033756 (+)
SPRET/EiJ ENSMSPG00010007284
 protein coding gene Chr16:41014977-41065395 (+)
WSB/EiJ ENSIUOG00005012962
 protein coding gene Chr16:41083848-41138091 (+)



Homology
more
  • Human Ortholog
    USF3, upstream transcription factor family member 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USF3, upstream transcription factor family member 3
  • Synonyms
    KIAA2018
  • Links
    NCBI Gene ID: 205717
    UniProt: Q68DE3

  • Chr Location
    3q13.2; chr3:113648385-113696646 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    630
  • Tissues
    24
  • cDNA Data
    70
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000068284 Ensembl Gene Model | MGI Sequence Detail 54220 C57BL/6J ±  kb
transcript ENSMUST00000119746 Ensembl | MGI Sequence Detail 12708 Not Applicable  
polypeptide ENSMUSP00000112620 Ensembl | MGI Sequence Detail 2221 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR036638 Helix-loop-helix DNA-binding domain superfamily
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR053252 Upstream transcription factor 3
    IPR048064 Upstream transcription factor 3, basic helix-loop-helix domain
  • GlyGen
    B2RUQ2 5 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 70
    cDNA 70

    Microarray probesets 4
Other
Accession IDs
less
MGI:1921751, MGI:2686625
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory