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Fbxo27 Gene Detail
Summary
  • Symbol
    Fbxo27
  • Name
    F-box protein 27
  • Synonyms
    E130008B10Rik, FBG5, LOC233040
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685007
    NCBI Gene: 233040
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28392274-28398763 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    299 from dbSNP Build 142
  • Strain Annotations
    24
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685007
 protein coding gene Chr7:28392205-28398763 (+)
129S1/SvImJ ENSMUSG00200041712
 protein coding gene Chr7:18179985-18180229 (+)
A/J ENSMUSG00195048874
 protein coding gene Chr7:20858483-20858727 (+)
AKR/J ENSMUSG00220046769
 protein coding gene Chr7:23633665-23633909 (-)
AKR/J ENSMUSGG00220054970
 protein coding gene Chr7:23627841-23632448 (-)
BALB/cJ ENSMUSG00180046385
 protein coding gene Chr7:18918048-18918292 (+)
C3H/HeJ ENSMUSG00175039186
 protein coding gene Chr7:19946976-19947220 (+)
C3H/HeJ ENSMUSGG00175055140
 protein coding gene Chr7:19948437-19953041 (+)
C57BL/6NJ ENSMUSG00215054299
 protein coding gene Chr7:18082635-18082879 (+)
C57BL/6NJ ENSMUSGG00215055841
 protein coding gene Chr7:18084096-18088701 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029455
 protein coding gene Chr7:27892867-27898862 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055076
 protein coding gene Chr7:19133025-19137627 (+)
CBA/J ENSMUSG00210051557
 protein coding gene Chr7:19131564-19131808 (+)
DBA/2J ENSMUSGG00185057382
 protein coding gene Chr7:22245745-22250350 (+)
DBA/2J ENSMUSG00185048860
 protein coding gene Chr7:22244284-22244528 (+)
FVB/NJ ENSMUSGG00205054662
 protein coding gene Chr7:18925234-18929842 (+)
FVB/NJ ENSMUSG00205050353
 protein coding gene Chr7:18923772-18924016 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055934
 protein coding gene Chr7:27416265-27420870 (+)
LP/J ENSMUSG00230051921
 protein coding gene Chr7:27414804-27415048 (+)
NOD/ShiLtJ ENSMUSGG00190054499
 protein coding gene Chr7:18580032-18584637 (+)
NOD/ShiLtJ ENSMUSG00190027444
 protein coding gene Chr7:18578571-18578815 (+)
NZO/HlLtJ ENSMUSGG00225055745
 protein coding gene Chr7:26259387-26263992 (+)
NZO/HlLtJ ENSMUSG00225024764
 protein coding gene Chr7:26257926-26258170 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010042676
 protein coding gene Chr7:17965076-17971553 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    FBXO27, F-box protein 27
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXO27, F-box protein 27
  • Synonyms
    FBG5, Fbx27
  • Links
    NCBI Gene ID: 126433
    UniProt: Q8NI29

  • Chr Location
    19q13.2; chr19:38990714-39033773 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    619
  • Tissues
    9
  • cDNA Data
    14
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037463 Ensembl Gene Model | MGI Sequence Detail 6490 C57BL/6J ±  kb
transcript ENSMUST00000108281 Ensembl | MGI Sequence Detail 1948 Not Applicable  
polypeptide ENSMUSP00000103916 Ensembl | MGI Sequence Detail 280 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:344665 Liu D, et al., The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes. Exp Mol Med. 2023 Sep;55(9):2025-2038
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory