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Sipa1l2 Gene Detail
Summary
  • Symbol
    Sipa1l2
  • Name
    signal-induced proliferation-associated 1 like 2
  • Synonyms
    mKIAA1389
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676970
    NCBI Gene: 244668
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:126144802-126296547 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 73.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4759 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676970
 protein coding gene Chr8:126144802-126296602 (-)
129S1/SvImJ ENSMUSG00200040947
 protein coding gene Chr8:120398432-120550643 (-)
A/J ENSMUSG00195024037
 protein coding gene Chr8:120673039-120825919 (-)
AKR/J ENSMUSG00220036284
 protein coding gene Chr8:120868220-121020290 (-)
BALB/cJ ENSMUSG00180022431
 protein coding gene Chr8:120717902-120870761 (-)
C3H/HeJ ENSMUSG00175029299
 protein coding gene Chr8:120789347-120942194 (-)
C57BL/6NJ ENSMUSG00215026567
 protein coding gene Chr8:120377616-120529389 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031720
 protein coding gene Chr8:116557313-116632468 (-)
CAST/EiJ ENSTCUG00005033151
 protein coding gene Chr8:120119417-120274364 (-)
CBA/J ENSMUSG00210036359
 protein coding gene Chr8:120708741-120860940 (-)
DBA/2J ENSMUSG00185035204
 protein coding gene Chr8:127027767-127179936 (-)
FVB/NJ ENSMUSG00205017256
 protein coding gene Chr8:119676384-119828596 (-)
JF1/MsJ ENSUMUG00000033585
 protein coding gene Chr8:129226292-129379150 (-)
LP/J ENSMUSG00230024004
 protein coding gene Chr8:130581030-130733241 (-)
NOD/ShiLtJ ENSMUSG00190017485
 protein coding gene Chr8:120835423-120987415 (-)
NZO/HlLtJ ENSMUSG00225019836
 protein coding gene Chr8:133940503-134092696 (-)
PWK/PhJ ENSLUMG00010032788
 protein coding gene Chr8:120510709-120664418 (-)
SPRET/EiJ ENSMSPG00010001595
 protein coding gene Chr8:122687763-122761557 (-)
WSB/EiJ ENSIUOG00005029973
 protein coding gene Chr8:121493284-121645826 (-)



Homology
more
  • Human Ortholog
    SIPA1L2, signal induced proliferation associated 1 like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIPA1L2, signal induced proliferation associated 1 like 2
  • Synonyms
    SPAL2, SPAR2
  • Links
    NCBI Gene ID: 57568
    UniProt: Q9P2F8

  • Chr Location
    1q42.2; chr1:232397622-232631404 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout results in neurological deficits relating to spatial pattern separation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    683
  • Tissues
    15
  • cDNA Data
    78
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001995 Ensembl Gene Model | MGI Sequence Detail 151746 C57BL/6J ±  kb
transcript ENSMUST00000108775 Ensembl | MGI Sequence Detail 6365 Not Applicable  
polypeptide ENSMUSP00000104405 Ensembl | MGI Sequence Detail 1722 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000014882 signal-induced proliferation-associated 1-like protein 2
    (term hierarchy)
  • InterPro Domains
    IPR001478 PDZ domain
    IPR036034 PDZ superfamily
    IPR050989 Rap1/Ran GTPase-activating
    IPR000331 Rap/Ran-GAP domain
    IPR035974 Rap/Ran-GAP superfamily
    IPR021818 Signal-induced proliferation-associated 1-like protein, C-terminal
  • GlyGen
    Q80TE4 7 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)
Molecular
Reagents
less
  • All nucleic 78
    cDNA 78

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:361037 Murray GC, et al., Testing SIPA1L2 as a modifier of CMT1A using mouse models. J Neuropathol Exp Neurol. 2024 Apr 19;83(5):318-330
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory