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Tnfsf18 Gene Detail
Summary
  • Symbol
    Tnfsf18
  • Name
    tumor necrosis factor (ligand) superfamily, member 18
  • Synonyms
    Gitrl, GITR ligand
  • Feature Type
    protein coding gene
  • IDs
    MGI:2673064
    NCBI Gene: 240873
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:161322224-161332859 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 69.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    299 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2673064
 protein coding gene Chr1:161322221-161333903 (+)
129S1/SvImJ ENSMUSG00200005999
 protein coding gene Chr1:158826930-158837564 (+)
A/J ENSMUSG00195018530
 protein coding gene Chr1:158143340-158153961 (+)
AKR/J ENSMUSG00220013848
 protein coding gene Chr1:157932900-157943535 (+)
BALB/cJ ENSMUSG00180036125
 protein coding gene Chr1:158404948-158415589 (+)
C3H/HeJ ENSMUSG00175038052
 protein coding gene Chr1:158461990-158472624 (+)
C57BL/6NJ ENSMUSG00215034758
 protein coding gene Chr1:158341161-158351796 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014765
 protein coding gene Chr1:152102252-152113471 (+)
CAST/EiJ ENSTCUG00005020006
 protein coding gene Chr1:156984934-156995569 (+)
CBA/J ENSMUSG00210020264
 protein coding gene Chr1:158359914-158370548 (+)
DBA/2J ENSMUSG00185010818
 protein coding gene Chr1:162622358-162632999 (+)
FVB/NJ ENSMUSG00205010050
 protein coding gene Chr1:157427947-157438582 (+)
JF1/MsJ ENSUMUG00000023186
 protein coding gene Chr1:161783405-161794040 (+)
LP/J ENSMUSG00230011810
 protein coding gene Chr1:162228285-162238919 (+)
NOD/ShiLtJ ENSMUSG00190034254
 protein coding gene Chr1:158179689-158190311 (+)
NZO/HlLtJ ENSMUSG00225002723
 protein coding gene Chr1:165828919-165839553 (+)
PWK/PhJ ENSLUMG00010037309
 protein coding gene Chr1:157153319-157163939 (+)
SPRET/EiJ ENSMSPG00010041876
 protein coding gene Chr1:160545768-160555504 (+)
WSB/EiJ ENSIUOG00005015080
 protein coding gene Chr1:157738443-157749067 (+)



Homology
more
  • Human Ortholog
    TNFSF18, TNF superfamily member 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFSF18, TNF superfamily member 18
  • Synonyms
    AITRL, GITRL, hGITRL, TL6, TNLG2A
  • Links
    NCBI Gene ID: 8995
    UniProt: Q9UNG2

  • Chr Location
    1q25.1; chr1:173039202-173050941 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Liver progenitor cell-specific conditional knock-out mice show attenuated ductular reaction, liver inflammation and liver fibrosis upon liver injury induced by feeding a choline-deficient diet supplemented with ethionine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    600
  • Tissues
    3
  • cDNA Data
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066755 Ensembl Gene Model | MGI Sequence Detail 10636 C57BL/6J ±  kb
    transcript ENSMUST00000086084 Ensembl | MGI Sequence Detail 2066 Not Applicable  
    polypeptide ENSMUSP00000083251 Ensembl | MGI Sequence Detail 173 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 1
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 1
      Gene Ontology 13
      Phenotypes 17
    • Earliest
      J:86980 Tone M, et al., Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15059-64
    • Latest
      J:346395 Li L, et al., GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR(+)CD8(+) T lymphocytes in CDE Mice. Cell Death Dis. 2024 Feb 6;15(2):114
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory