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Gpr119 Gene Detail
Summary
  • Symbol
    Gpr119
  • Name
    G-protein coupled receptor 119
Location &
Maps
more
  • Sequence Map
    ChrX:47756856-47763355 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 25.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2668412
 protein coding gene ChrX:47756856-47763355 (-)
129S1/SvImJ ENSMUSG00200037708
 protein coding gene ChrX:31794222-31800725 (-)
A/J ENSMUSG00195017045
 protein coding gene ChrX:34395881-34402385 (-)
AKR/J ENSMUSG00220036559
 protein coding gene ChrX:31284292-31290796 (-)
BALB/cJ ENSMUSG00180031625
 protein coding gene ChrX:32125776-32132280 (-)
C3H/HeJ ENSMUSG00175038604
 protein coding gene ChrX:35144410-35150914 (-)
C57BL/6NJ ENSMUSG00215047113
 protein coding gene ChrX:32131749-32138248 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033047
 protein coding gene ChrX:41374028-41380485 (-)
CAST/EiJ ENSTCUG00005037695
 protein coding gene ChrX:34218323-34224652 (-)
CBA/J ENSMUSG00210038137
 protein coding gene ChrX:32387928-32394432 (-)
DBA/2J ENSMUSG00185033122
 protein coding gene ChrX:43094324-43100828 (-)
FVB/NJ ENSMUSG00205021935
 protein coding gene ChrX:31074590-31081094 (-)
JF1/MsJ ENSUMUG00000024301
 protein coding gene ChrX:62141765-62148059 (-)
LP/J ENSMUSG00230019148
 protein coding gene ChrX:49626639-49633143 (-)
NOD/ShiLtJ ENSMUSG00190027063
 protein coding gene ChrX:31563549-31570053 (-)
NZO/HlLtJ ENSMUSG00225042838
 protein coding gene ChrX:54820287-54826790 (-)
PWK/PhJ ENSLUMG00010038311
 protein coding gene ChrX:31859139-31865431 (-)
SPRET/EiJ ENSMSPG00010024176
 protein coding gene ChrX:33456862-33458093 (-)
WSB/EiJ ENSIUOG00005046066
 protein coding gene ChrX:32667851-32674352 (-)



Homology
more
  • Human Ortholog
    GPR119, G protein-coupled receptor 119
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR119, G protein-coupled receptor 119
  • Synonyms
    GPCR2
  • Links
    NCBI Gene ID: 139760
    UniProt: Q8TDV5

  • Chr Location
    Xq26.1; chrX:130379449-130385674 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal growth and glucose homeostasis except lowered body weight when fed a low-fat diet and decreased insulin levels post-glucose load.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    653
  • Tissues
    55
  • cDNA Data
    4
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 236781 NCBI Gene Model | MGI Sequence Detail 6500 C57BL/6J ±  kb
    transcript NM_181751 RefSeq | MGI Sequence Detail 2278 Not Specified  
    polypeptide Q7TQP3 UniProt | EBI | MGI Sequence Detail 335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 4
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:94969 Soga T, et al., Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun. 2005 Jan 28;326(4):744-51
    • Latest
      J:366521 Lee JE, et al., Oleoylethanolamide ameliorates collagen-induced rheumatoid arthritis via activation of GPR119. Int Immunopharmacol. 2025 May 16;155:114660
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory