About   Help   FAQ
Cog3 Gene Detail
Summary
  • Symbol
    Cog3
  • Name
    component of oligomeric golgi complex 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450151
    NCBI Gene: 338337
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:75939790-75991998 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 40.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1258 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2450151
 protein coding gene Chr14:75939790-75992078 (-)
129S1/SvImJ ENSMUSG00200009407
 protein coding gene Chr14:64364135-64417015 (-)
A/J ENSMUSG00195003955
 protein coding gene Chr14:64516300-64568943 (-)
AKR/J ENSMUSG00220007080
 protein coding gene Chr14:63903820-63956418 (-)
BALB/cJ ENSMUSG00180021686
 protein coding gene Chr14:64108297-64160932 (-)
C3H/HeJ ENSMUSG00175026756
 protein coding gene Chr14:65925002-65977593 (-)
C57BL/6NJ ENSMUSG00215014294
 protein coding gene Chr14:64103572-64156200 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019516
 protein coding gene Chr14:66583261-66636159 (-)
CAST/EiJ ENSTCUG00005030764
 protein coding gene Chr14:65755130-65807324 (-)
CBA/J ENSMUSG00210009584
 protein coding gene Chr14:64539664-64592262 (-)
DBA/2J ENSMUSG00185022342
 protein coding gene Chr14:69684241-69736838 (-)
FVB/NJ ENSMUSG00205024039
 protein coding gene Chr14:63931841-63984473 (-)
JF1/MsJ ENSUMUG00000016389
 protein coding gene Chr14:80837259-80889892 (-)
LP/J ENSMUSG00230014560
 protein coding gene Chr14:81714123-81767001 (-)
NOD/ShiLtJ ENSMUSG00190010494
 protein coding gene Chr14:64314642-64367175 (-)
NZO/HlLtJ ENSMUSG00225025177
 protein coding gene Chr14:72022372-72075026 (-)
PWK/PhJ ENSLUMG00010010287
 protein coding gene Chr14:63717889-63770520 (-)
SPRET/EiJ ENSMSPG00010026472
 protein coding gene Chr14:67357589-67410311 (-)
WSB/EiJ ENSIUOG00005021629
 protein coding gene Chr14:63685726-63738831 (-)



Homology
more
  • Human Ortholog
    COG3, component of oligomeric golgi complex 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COG3, component of oligomeric golgi complex 3
  • Synonyms
    CDG2BB, SEC34
  • Links
    NCBI Gene ID: 83548
    UniProt: Q96JB2

  • Chr Location
    13q14.13; chr13:45464898-45536701 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human COG3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    6
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034893 Ensembl Gene Model | MGI Sequence Detail 52209 C57BL/6J ±  kb
    transcript ENSMUST00000049168 Ensembl | MGI Sequence Detail 4268 Not Applicable  
    polypeptide ENSMUSP00000045016 Ensembl | MGI Sequence Detail 828 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005686 conserved oligomeric Golgi complex subunit 3
      (term hierarchy)
    • InterPro Domains
      IPR063408 COG3, C-terminal cap domain
      IPR007265 Conserved oligomeric Golgi complex, subunit 3
      IPR048685 Conserved oligomeric Golgi complex subunit 3, C-terminal
      IPR048320 Conserved oligomeric Golgi complex subunit 3, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory