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Gemin4 Gene Detail
Summary
  • Symbol
    Gemin4
  • Name
    gem nuclear organelle associated protein 4
  • Synonyms
    MGC:28146
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449313
    NCBI Gene: 276919
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:76101397-76108398 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    180 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449313
 protein coding gene Chr11:76101397-76108490 (-)
129S1/SvImJ ENSMUSGG00200054889
 protein coding gene Chr11:73233229-73240317 (-)
A/J ENSMUSGG00195054952
 protein coding gene Chr11:73111677-73118765 (-)
AKR/J ENSMUSGG00220054873
 protein coding gene Chr11:73326900-73333988 (-)
BALB/cJ ENSMUSGG00180055059
 protein coding gene Chr11:73300133-73307222 (-)
C3H/HeJ ENSMUSGG00175055115
 protein coding gene Chr11:73270029-73277117 (-)
C57BL/6NJ ENSMUSGG00215055255
 protein coding gene Chr11:72877865-72884958 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016756
 protein coding gene Chr11:71151921-71158951 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054985
 protein coding gene Chr11:73088478-73095566 (-)
DBA/2J ENSMUSGG00185057879
 protein coding gene Chr11:73358486-73365574 (-)
FVB/NJ ENSMUSGG00205054077
 protein coding gene Chr11:73195107-73202195 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055871
 protein coding gene Chr11:74389075-74396163 (-)
NOD/ShiLtJ ENSMUSGG00190054536
 protein coding gene Chr11:73405375-73412464 (-)
NZO/HlLtJ ENSMUSGG00225055702
 protein coding gene Chr11:76548630-76555718 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GEMIN4, gem nuclear organelle associated protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GEMIN4, gem nuclear organelle associated protein 4
  • Synonyms
    HC56, HCAP1, HHRF-1, NEDMCR, p97
  • Links
    NCBI Gene ID: 50628
    UniProt: P57678

  • Chr Location
    17p13.3; chr17:744421-754410 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GEMIN4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele die before E5.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    609
  • Tissues
    6
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 276919 NCBI Gene Model | MGI Sequence Detail 7002 C57BL/6J ±  kb
    transcript NM_177367 RefSeq | MGI Sequence Detail 3448 C57BL/6  
    polypeptide NP_796341 RefSeq | MGI Sequence Detail 1058 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR056581 Edg1/GEMIN4, TPR repeats region
      IPR033265 Gem-associated protein 4
    • GlyGen
      Q6P6L6 1 site
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144371
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory