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Pdap1 Gene Detail
Summary
  • Symbol
    Pdap1
  • Name
    PDGFA associated protein 1
  • Synonyms
    HASPP28, PAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448536
    NCBI Gene: 231887
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:145065580-145076835 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 85.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    334 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448536
 protein coding gene Chr5:145065579-145077048 (-)
129S1/SvImJ ENSMUSG00200040133
 protein coding gene Chr5:138906411-138917850 (-)
A/J ENSMUSG00195042655
 protein coding gene Chr5:138565096-138576565 (-)
AKR/J ENSMUSG00220020509
 protein coding gene Chr5:137791116-137802555 (-)
BALB/cJ ENSMUSG00180027088
 protein coding gene Chr5:138667045-138678515 (-)
C3H/HeJ ENSMUSG00175045232
 protein coding gene Chr5:140592492-140603961 (-)
C57BL/6NJ ENSMUSG00215039687
 protein coding gene Chr5:138515616-138527086 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028009
 protein coding gene Chr5:137823035-137834677 (-)
CAST/EiJ ENSTCUG00005032839
 protein coding gene Chr5:137949389-137960906 (-)
CBA/J ENSMUSG00210023121
 protein coding gene Chr5:139407902-139419341 (-)
DBA/2J ENSMUSG00185038273
 protein coding gene Chr5:142395393-142406862 (-)
FVB/NJ ENSMUSG00205038369
 protein coding gene Chr5:138210397-138221870 (-)
JF1/MsJ ENSUMUG00000044208
 protein coding gene Chr5:145271378-145282861 (-)
LP/J ENSMUSG00230024552
 protein coding gene Chr5:146510050-146521489 (-)
NOD/ShiLtJ ENSMUSG00190027328
 protein coding gene Chr5:138349053-138360525 (-)
NZO/HlLtJ ENSMUSG00225007867
 protein coding gene Chr5:153983355-153994802 (-)
PWK/PhJ ENSLUMG00010018636
 protein coding gene Chr5:136982703-136994194 (-)
SPRET/EiJ ENSMSPG00010028431
 protein coding gene Chr5:140593201-140605121 (-)
WSB/EiJ ENSIUOG00005029480
 protein coding gene Chr5:140892317-140903760 (-)



Homology
more
  • Human Ortholog
    PDAP1, PDGFA associated protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDAP1, PDGFA associated protein 1
  • Synonyms
    HASPP28, PAP, PAP1
  • Links
    NCBI Gene ID: 11333
    UniProt: Q13442

  • Chr Location
    7q22.1; chr7:99392048-99408665 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    17
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 231887 NCBI Gene Model | MGI Sequence Detail 11256 C57BL/6J ±  kb
transcript NM_001033313 RefSeq | MGI Sequence Detail 2139 C57BL/6  
polypeptide Q3UHX2 UniProt | EBI | MGI Sequence Detail 181 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012449 28 kDa heat- and acid-stable phosphoprotein
    (term hierarchy)
  • InterPro Domains
    IPR039876 28kDa heat- and acid-stable phosphoprotein
    IPR019380 Casein kinase substrate, phosphoprotein PP28
  • GlyGen
    Q3UHX2 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 6
References
more
  • Summaries
    All 39
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:391699 Yang T, et al., Deficiency of Pdap1 Results in Embryonic Lethality and Diminished Vascularization. FASEB J. 2026 Jan 31;40(2):e71437
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory