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Pde2a Gene Detail
Summary
  • Symbol
    Pde2a
  • Name
    phosphodiesterase 2A, cGMP-stimulated
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446107
    NCBI Gene: 207728
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101070905-101162026 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2202 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446107
 protein coding gene Chr7:101070898-101162034 (+)
129S1/SvImJ ENSMUSG00200043784
 protein coding gene Chr7:87902876-87994000 (+)
A/J ENSMUSG00195054323
 protein coding gene Chr7:92408461-92499599 (+)
AKR/J ENSMUSG00220045813
 protein coding gene Chr7:85825088-85916227 (+)
BALB/cJ ENSMUSG00180029420
 protein coding gene Chr7:89081549-89172523 (+)
C3H/HeJ ENSMUSG00175020801
 protein coding gene Chr7:89743501-89835535 (+)
C57BL/6NJ ENSMUSG00215022757
 protein coding gene Chr7:88917772-89008921 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005053099
 protein coding gene Chr7:92327139-92418435 (+)
CBA/J ENSMUSG00210024592
 protein coding gene Chr7:89596954-89688984 (+)
DBA/2J ENSMUSG00185055994
 protein coding gene Chr7:93918638-94010669 (+)
FVB/NJ ENSMUSG00205034573
 protein coding gene Chr7:89579611-89670735 (+)
JF1/MsJ ENSUMUG00000035375
 protein coding gene Chr7:98819512-98911474 (+)
LP/J ENSMUSG00230041096
 protein coding gene Chr7:100044735-100135856 (+)
NOD/ShiLtJ ENSMUSG00190018271
 protein coding gene Chr7:89859947-89951064 (+)
NZO/HlLtJ ENSMUSG00225048924
 protein coding gene Chr7:98222869-98313948 (+)
PWK/PhJ ENSLUMG00010048700
 protein coding gene Chr7:88069864-88161686 (+)
SPRET/EiJ ENSMSPG00010010153
 protein coding gene Chr7:89307485-89398414 (+)
WSB/EiJ ENSIUOG00005010175
 protein coding gene Chr7:90209073-90300205 (+)



Homology
more
  • Human Ortholog
    PDE2A, phosphodiesterase 2A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE2A, phosphodiesterase 2A
  • Synonyms
    cGSPDE, CGS-PDE, IDDPADS, PDE2A1, PED2A4
  • Links
    NCBI Gene ID: 5138
    UniProt: O00408

  • Chr Location
    11q13.4; chr11:72576141-72674591 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality between E17 and E18; another knock out mutation results in only some animals surviving to weaning age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    138
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    150
  • cDNA Data
    91
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 207728 NCBI Gene Model | MGI Sequence Detail 91122 C57BL/6J ±  kb
    transcript NM_001420545 RefSeq | MGI Sequence Detail 4265 C57BL/6  
    polypeptide Q922S4 UniProt | EBI | MGI Sequence Detail 939 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000012469 cGMP-dependent 3',5'-cyclic phosphodiesterase
      (term hierarchy)
    • PDB
      1MC0
    • EC
      3.1.4.-, 3.1.4.17
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR003018 GAF domain
      IPR029016 GAF-like domain superfamily
      IPR003607 HD/PDEase domain
    • GlyGen
      Q922S4 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 92
      cDNA 91
      Primer pair 1
      Antibodies 3

      Microarray probesets 7
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 11
      Gene Ontology 20
      Phenotypes 31
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:391218 Firneburg R, et al., The CNP analogue vosoritide mediates PDE2-sensitive anti-arrhythmogenic effects in mouse hearts with STZ-induced type 1 diabetes. Basic Res Cardiol. 2025 Dec;120(6):1173-1191
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory