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Kmt5b Gene Detail
Summary
  • Symbol
    Kmt5b
  • Name
    lysine methyltransferase 5B
  • Synonyms
    C630029K18Rik, Suv4-20h1, Suv420h1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444557
    NCBI Gene: 225888
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:3817421-3868303 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.50 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1049 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444557
 protein coding gene Chr19:3816436-3868303 (+)
129S1/SvImJ ENSMUSG00200052269
 protein coding gene Chr19:578173-628325 (+)
A/J ENSMUSG00195051330
 protein coding gene Chr19:969446-1019589 (+)
AKR/J ENSMUSG00220046865
 protein coding gene Chr19:742412-792567 (+)
BALB/cJ ENSMUSG00180040879
 protein coding gene Chr19:1344163-1394313 (+)
C3H/HeJ ENSMUSG00175008785
 protein coding gene Chr19:588949-639100 (+)
C57BL/6NJ ENSMUSG00215041492
 protein coding gene Chr19:816435-866595 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022471
 protein coding gene Chr19:511330-561313 (+)
CAST/EiJ ENSTCUG00005040319
 protein coding gene Chr19:730745-780746 (+)
CBA/J ENSMUSG00210042721
 protein coding gene Chr19:589324-639462 (+)
DBA/2J ENSMUSG00185046500
 protein coding gene Chr19:965645-1015783 (+)
FVB/NJ ENSMUSG00205021532
 protein coding gene Chr19:971041-1021312 (+)
JF1/MsJ ENSUMUG00000045220
 protein coding gene Chr19:954400-1004689 (+)
LP/J ENSMUSG00230054092
 protein coding gene Chr19:1884352-1934506 (+)
NOD/ShiLtJ ENSMUSG00190042311
 protein coding gene Chr19:510552-560703 (+)
NZO/HlLtJ ENSMUSG00225025108
 protein coding gene Chr19:5593196-5643351 (+)
PWK/PhJ ENSLUMG00010004157
 protein coding gene Chr19:725228-775100 (+)
SPRET/EiJ ENSMSPG00010036621
 protein coding gene Chr19:706712-756071 (+)
WSB/EiJ ENSIUOG00005044315
 protein coding gene Chr19:595531-645527 (+)



Homology
more
  • Human Ortholog
    KMT5B, lysine methyltransferase 5B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KMT5B, lysine methyltransferase 5B
  • Synonyms
    CGI-85, CGI85, MRD51, SUV420H1
  • Links
    NCBI Gene ID: 51111
    UniProt: Q4FZB7

  • Chr Location
    11q13.2; chr11:68154863-68213852 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KMT5B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    1 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are born at sub-Mendelian ratios, are smaller than control littermates, and die within a few hours of birth, probably due to alveolar defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    874
  • Tissues
    234
  • cDNA Data
    21
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045098 Ensembl Gene Model | MGI Sequence Detail 50883 C57BL/6J ±  kb
    transcript ENSMUST00000113972 Ensembl | MGI Sequence Detail 4159 Not Applicable  
    polypeptide ENSMUSP00000109605 Ensembl | MGI Sequence Detail 883 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:3034400
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 9
      Gene Ontology 12
      Phenotypes 26
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:389441 Schwarz LA, et al., Cortical development dynamics across autism spectrum disorder mouse models. Nature. 2026 Jun 17;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory