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Ythdc1 Gene Detail
Summary
  • Symbol
    Ythdc1
  • Name
    YTH domain containing 1
  • Synonyms
    A730098D12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443713
    NCBI Gene: 231386
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:86952080-86984518 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 43.56 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    693 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443713
 protein coding gene Chr5:86951349-86984518 (+)
129S1/SvImJ ENSMUSG00200008398
 protein coding gene Chr5:82692028-82724465 (+)
A/J ENSMUSG00195024144
 protein coding gene Chr5:81853407-81885847 (+)
AKR/J ENSMUSG00220010823
 protein coding gene Chr5:81987331-82019769 (+)
BALB/cJ ENSMUSG00180000066
 protein coding gene Chr5:81683951-81716393 (+)
C3H/HeJ ENSMUSG00175042272
 protein coding gene Chr5:83762077-83794518 (+)
C57BL/6NJ ENSMUSG00215028132
 protein coding gene Chr5:82546474-82578915 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027347
 protein coding gene Chr5:79875173-79908538 (+)
CAST/EiJ ENSTCUG00005033294
 protein coding gene Chr5:81325248-81357673 (+)
CBA/J ENSMUSG00210005145
 protein coding gene Chr5:82580910-82613351 (+)
DBA/2J ENSMUSG00185037333
 protein coding gene Chr5:84500054-84532495 (+)
FVB/NJ ENSMUSG00205001092
 protein coding gene Chr5:81384852-81417292 (+)
JF1/MsJ ENSUMUG00000000824
 protein coding gene Chr5:88890310-88923681 (+)
LP/J ENSMUSG00230001376
 protein coding gene Chr5:89221994-89254427 (+)
NOD/ShiLtJ ENSMUSG00190029946
 protein coding gene Chr5:81442229-81474669 (+)
NZO/HlLtJ ENSMUSG00225008391
 protein coding gene Chr5:94246586-94279022 (+)
PWK/PhJ ENSLUMG00010027329
 protein coding gene Chr5:81381811-81415408 (+)
SPRET/EiJ ENSMSPG00010029454
 protein coding gene Chr5:83596301-83629103 (+)
WSB/EiJ ENSIUOG00005028645
 protein coding gene Chr5:84404115-84436532 (+)



Homology
more
  • Human Ortholog
    YTHDC1, YTH N6-methyladenosine RNA binding protein C1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YTHDC1, YTH N6-methyladenosine RNA binding protein C1
  • Synonyms
    YT521, YT521-B
  • Links
    NCBI Gene ID: 91746
    UniProt: Q96MU7

  • Chr Location
    4q13.2; chr4:68310387-68350098 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die between E8.5 and E11.5. Mice homozygous for a cconditional allele activated after embryonic development exhibit infertility with defects in spermatogenesis and oogenesis associated with RNA granules and altered transcription in oocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    3
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035851 Ensembl Gene Model | MGI Sequence Detail 32439 C57BL/6J ±  kb
    transcript ENSMUST00000038384 Ensembl | MGI Sequence Detail 2960 Not Applicable  
    polypeptide ENSMUSP00000039133 Ensembl | MGI Sequence Detail 736 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 26
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:371297 Wang L, et al., YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARgamma. EMBO J. 2025 Jun;44(12):3360-3380
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory