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Ddx11 Gene Detail
Summary
  • Symbol
    Ddx11
  • Name
    DEAD/H box helicase 11
  • Synonyms
    4732462I11Rik, CHL1, CHLR1, DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11, essa15a, KRG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443590
    NCBI Gene: 320209
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:66430515-66459169 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 35.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1101 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443590
 protein coding gene Chr17:66430508-66459169 (+)
129S1/SvImJ ENSMUSG00200038551
 protein coding gene Chr17:61779771-61808426 (+)
A/J ENSMUSG00195017076
 protein coding gene Chr17:63122227-63150878 (+)
AKR/J ENSMUSG00220017750
 protein coding gene Chr17:62193777-62222433 (+)
BALB/cJ ENSMUSG00180018830
 protein coding gene Chr17:62859611-62888262 (+)
C3H/HeJ ENSMUSG00175029990
 protein coding gene Chr17:62166930-62195584 (+)
C57BL/6NJ ENSMUSG00215021909
 protein coding gene Chr17:61818651-61847311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021837
 protein coding gene Chr17:62274028-62300554 (+)
CAST/EiJ ENSTCUG00005025323
 protein coding gene Chr17:62776776-62820699 (+)
CBA/J ENSMUSG00210028658
 protein coding gene Chr17:61966832-61995488 (+)
DBA/2J ENSMUSG00185022480
 protein coding gene Chr17:64811513-64840160 (+)
FVB/NJ ENSMUSG00205017491
 protein coding gene Chr17:62586062-62614713 (+)
JF1/MsJ ENSUMUG00000035282
 protein coding gene Chr17:64463019-64504963 (+)
LP/J ENSMUSG00230013445
 protein coding gene Chr17:65798022-65826676 (+)
NOD/ShiLtJ ENSMUSG00190034490
 protein coding gene Chr17:61945973-61974621 (+)
NZO/HlLtJ ENSMUSG00225025919
 protein coding gene Chr17:68073166-68101810 (+)
PWK/PhJ ENSLUMG00010027964
 protein coding gene Chr17:61747441-61789369 (+)
SPRET/EiJ ENSMSPG00010015688
 protein coding gene Chr17:62113388-62141986 (+)
WSB/EiJ ENSIUOG00005029795
 protein coding gene Chr17:62801823-62830451 (+)



Homology
more
  • Human Ortholog
    DDX11, DEAD/H-box helicase 11
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX11, DEAD/H-box helicase 11
  • Synonyms
    CHL1, CHLR1, KRG2, WABS
  • Links
    NCBI Gene ID: 1663
    UniProt: Q96FC9

  • Chr Location
    12p11.21; chr12:31073282-31104811 (+)  GRCh38
  • Human Ortholog
    DDX11L8, DEAD/H-box helicase 11 like 8 (pseudogene)
  • Links
    NCBI Gene ID: 100302090
    UniProt: A8MPP1

  • Chr Location
    chr12:12310-14526 (+)  GRCh38
  • Human Ortholog
    DDX12P, DEAD/H-box helicase 12, pseudogene
  • Synonyms
    CHLR2, DDX12
  • Links
    NCBI Gene ID: 440081
    UniProt: Q92771

  • Chr Location
    12p13.31; chr12:9417691-9448229 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DDX11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit lethality before E11.5 with growth retardation, failure of chorioallantoic fusion, poor placental labyrinth development, and embryonic cell physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    7
  • cDNA Data
    30
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035842 Ensembl Gene Model | MGI Sequence Detail 28655 C57BL/6J ±  kb
    transcript ENSMUST00000224497 Ensembl | MGI Sequence Detail 4141 Not Applicable  
    polypeptide ENSMUSP00000153436 Ensembl | MGI Sequence Detail 906 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 30
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3578202
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory