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Slc4a5 Gene Detail
Summary
  • Symbol
    Slc4a5
  • Name
    solute carrier family 4, sodium bicarbonate cotransporter, member 5
  • Synonyms
    C330016K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443220
    NCBI Gene: 232156
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83196810-83281927 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2728 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443220
 protein coding gene Chr6:83184561-83281927 (+)
129S1/SvImJ ENSMUSG00200011584
 protein coding gene Chr6:80165885-80250840 (+)
A/J ENSMUSG00195011756
 protein coding gene Chr6:79842705-79927656 (+)
AKR/J ENSMUSG00220001923
 protein coding gene Chr6:78786258-78871922 (+)
BALB/cJ ENSMUSG00180009709
 protein coding gene Chr6:80218690-80303672 (+)
C3H/HeJ ENSMUSG00175031676
 protein coding gene Chr6:97105939-97191107 (-)
C57BL/6NJ ENSMUSG00215008110
 protein coding gene Chr6:80216415-80301576 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028552
 protein coding gene Chr6:79373159-79451059 (+)
CAST/EiJ ENSTCUG00005008223
 protein coding gene Chr6:80227966-80313069 (+)
CBA/J ENSMUSG00210010846
 protein coding gene Chr6:80034767-80119926 (+)
DBA/2J ENSMUSG00185000930
 protein coding gene Chr6:80581840-80667001 (+)
FVB/NJ ENSMUSG00205015470
 protein coding gene Chr6:79260384-79345344 (+)
JF1/MsJ ENSUMUG00000010696
 protein coding gene Chr6:79634509-79721007 (+)
LP/J ENSMUSG00230049978
 protein coding gene Chr6:81723137-81808086 (+)
NOD/ShiLtJ ENSMUSG00190001256
 protein coding gene Chr6:79663500-79748464 (+)
NZO/HlLtJ ENSMUSG00225017859
 protein coding gene Chr6:83635905-83715406 (+)
PWK/PhJ ENSLUMG00010005002
 protein coding gene Chr6:78985147-79074328 (+)
SPRET/EiJ ENSMSPG00010036009
 protein coding gene Chr6:81141031-81224882 (+)
WSB/EiJ ENSIUOG00005017150
 protein coding gene Chr6:80602175-80687146 (+)



Homology
more
  • Human Ortholog
    SLC4A5, solute carrier family 4 member 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC4A5, solute carrier family 4 member 5
  • Synonyms
    NBC4, NBCe2
  • Links
    NCBI Gene ID: 57835
    UniProt: Q9BY07

  • Chr Location
    2p13.1; chr2:74216242-74343416 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit arterial hypertension and renal metabolic acidosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    98
  • cDNA Data
    25
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068323 Ensembl Gene Model | MGI Sequence Detail 85118 C57BL/6J ±  kb
    transcript ENSMUST00000113900 Ensembl | MGI Sequence Detail 3630 Not Applicable  
    polypeptide ENSMUSP00000109533 Ensembl | MGI Sequence Detail 1116 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 25
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory