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Wdr3 Gene Detail
Summary
  • Symbol
    Wdr3
  • Name
    WD repeat domain 3
  • Synonyms
    D030020G18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443143
    NCBI Gene: 269470
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:100045496-100069723 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 43.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    748 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443143
 protein coding gene Chr3:100045496-100069723 (-)
129S1/SvImJ ENSMUSG00200041017
 protein coding gene Chr3:96649764-96673987 (-)
A/J ENSMUSG00195045664
 protein coding gene Chr3:97043638-97067906 (-)
AKR/J ENSMUSG00220035519
 protein coding gene Chr3:95403760-95428026 (-)
BALB/cJ ENSMUSG00180038893
 protein coding gene Chr3:96983244-97007511 (-)
C3H/HeJ ENSMUSG00175022532
 protein coding gene Chr3:96529582-96553852 (-)
C57BL/6NJ ENSMUSG00215019143
 protein coding gene Chr3:97307143-97331370 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025421
 protein coding gene Chr3:94265644-94290115 (-)
CAST/EiJ ENSTCUG00005018518
 protein coding gene Chr3:97253111-97277623 (-)
CBA/J ENSMUSG00210050643
 protein coding gene Chr3:97151787-97176053 (-)
DBA/2J ENSMUSG00185039136
 protein coding gene Chr3:97631376-97655602 (-)
FVB/NJ ENSMUSG00205022532
 protein coding gene Chr3:96226714-96250944 (-)
JF1/MsJ ENSUMUG00000043462
 protein coding gene Chr3:96353688-96377932 (-)
LP/J ENSMUSG00230045087
 protein coding gene Chr3:99578478-99602707 (-)
NOD/ShiLtJ ENSMUSG00190033967
 protein coding gene Chr3:97830889-97855118 (-)
NZO/HlLtJ ENSMUSG00225016626
 protein coding gene Chr3:102011322-102035588 (-)
PWK/PhJ ENSLUMG00010025471
 protein coding gene Chr3:96439825-96464024 (-)
SPRET/EiJ ENSMSPG00010041777
 protein coding gene Chr3:96682780-96707387 (-)
WSB/EiJ ENSIUOG00005025902
 protein coding gene Chr3:97160492-97184763 (-)



Homology
more
  • Human Ortholog
    WDR3, WD repeat domain 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR3, WD repeat domain 3
  • Synonyms
    DIP2, UTP12
  • Links
    NCBI Gene ID: 10885
    UniProt: Q9UNX4

  • Chr Location
    1p12; chr1:117929063-117966543 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human WDR3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete prenatal lethality. Heterozygotes show normal growth and brain anatomy but exhibit a slight but significant increase in spontaneous locomotor activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    600
  • Tissues
    3
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 269470 NCBI Gene Model | MGI Sequence Detail 24228 C57BL/6J ±  kb
transcript NM_175552 RefSeq | MGI Sequence Detail 3444 C57BL/6  
polypeptide Q8BHB4 UniProt | EBI | MGI Sequence Detail 942 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:2139997
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory