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Atad5 Gene Detail
Summary
  • Symbol
    Atad5
  • Name
    ATPase family, AAA domain containing 5
  • Synonyms
    C130052G03Rik, LOC237877
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442925
    NCBI Gene: 237877
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:79980226-80026620 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 47.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    937 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442925
 protein coding gene Chr11:79980205-80026623 (+)
129S1/SvImJ ENSMUSG00200049198
 protein coding gene Chr11:77100434-77146830 (+)
A/J ENSMUSG00195044064
 protein coding gene Chr11:76979357-77025770 (+)
AKR/J ENSMUSG00220047639
 protein coding gene Chr11:77201040-77247448 (+)
BALB/cJ ENSMUSG00180041172
 protein coding gene Chr11:77162080-77208497 (+)
C3H/HeJ ENSMUSG00175032243
 protein coding gene Chr11:77144247-77190641 (+)
C57BL/6NJ ENSMUSG00215039155
 protein coding gene Chr11:76761315-76807715 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016831
 protein coding gene Chr11:75040540-75088461 (+)
CAST/EiJ ENSTCUG00005043221
 protein coding gene Chr11:76656434-76702215 (+)
CBA/J ENSMUSG00210031984
 protein coding gene Chr11:76967870-77014266 (+)
DBA/2J ENSMUSG00185032296
 protein coding gene Chr11:77225757-77272151 (+)
FVB/NJ ENSMUSG00205044839
 protein coding gene Chr11:77041911-77088307 (+)
JF1/MsJ ENSUMUG00000049247
 protein coding gene Chr11:77604502-77650019 (+)
LP/J ENSMUSG00230046874
 protein coding gene Chr11:78256025-78302417 (+)
NOD/ShiLtJ ENSMUSG00190041337
 protein coding gene Chr11:77272689-77319083 (+)
NZO/HlLtJ ENSMUSG00225037959
 protein coding gene Chr11:80423583-80469980 (+)
PWK/PhJ ENSLUMG00010018819
 protein coding gene Chr11:77133207-77177685 (+)
SPRET/EiJ ENSMSPG00010036252
 protein coding gene Chr11:77515837-77560210 (+)
WSB/EiJ ENSIUOG00005032594
 protein coding gene Chr11:77108182-77154595 (+)



Homology
more
  • Human Ortholog
    ATAD5, ATPase family AAA domain containing 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATAD5, ATPase family AAA domain containing 5
  • Synonyms
    C17orf41, ELG1, FRAG1
  • Links
    NCBI Gene ID: 79915
    UniProt: Q96QE3

  • Chr Location
    17q11.2; chr17:30831966-30895869 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit prenatal lethality. Mice heterozygous for a gene trap allele exhibit genomic instability, premature death, and a wide spectrum of spontaneous tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    663
  • Tissues
    5
  • cDNA Data
    67
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017550 Ensembl Gene Model | MGI Sequence Detail 46395 C57BL/6J ±  kb
    transcript ENSMUST00000017694 Ensembl | MGI Sequence Detail 7272 Not Applicable  
    polypeptide ENSMUSP00000017694 Ensembl | MGI Sequence Detail 1826 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004394 ATPase family AAA domain-containing protein 5
      (term hierarchy)
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR003959 ATPase, AAA-type, core
      IPR060636 Enhanced level of genomic instability 1-like, C-terminal domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q4QY64 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 67

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2684863
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory