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Usp37 Gene Detail
Summary
  • Symbol
    Usp37
  • Name
    ubiquitin specific peptidase 37
  • Synonyms
    4932415L06Rik, C330008N13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442483
    NCBI Gene: 319651
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74474670-74583443 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2243 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442483
 protein coding gene Chr1:74474669-74583447 (-)
129S1/SvImJ ENSMUSG00200032045
 protein coding gene Chr1:72137833-72246481 (-)
A/J ENSMUSG00195008262
 protein coding gene Chr1:71562715-71671360 (-)
AKR/J ENSMUSG00220010277
 protein coding gene Chr1:71708530-71817164 (-)
BALB/cJ ENSMUSG00180016916
 protein coding gene Chr1:71821352-71930143 (-)
C3H/HeJ ENSMUSG00175015158
 protein coding gene Chr1:71963103-72071727 (-)
C57BL/6NJ ENSMUSG00215010078
 protein coding gene Chr1:71866673-71975465 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014264
 protein coding gene Chr1:67994693-68065865 (-)
CAST/EiJ ENSTCUG00005027179
 protein coding gene Chr1:71590914-71700197 (-)
CBA/J ENSMUSG00210033185
 protein coding gene Chr1:71647290-71755929 (-)
DBA/2J ENSMUSG00185029690
 protein coding gene Chr1:72741159-72849725 (-)
FVB/NJ ENSMUSG00205032651
 protein coding gene Chr1:71316276-71425078 (-)
JF1/MsJ ENSUMUG00000004602
 protein coding gene Chr1:71641273-71749790 (-)
LP/J ENSMUSG00230009685
 protein coding gene Chr1:72731017-72839657 (-)
NOD/ShiLtJ ENSMUSG00190032934
 protein coding gene Chr1:71873131-71981696 (-)
NZO/HlLtJ ENSMUSG00225038612
 protein coding gene Chr1:75946120-76054766 (-)
PWK/PhJ ENSLUMG00010012997
 protein coding gene Chr1:71217361-71333783 (-)
SPRET/EiJ ENSMSPG00010017732
 protein coding gene Chr1:73318292-73382807 (-)
WSB/EiJ ENSIUOG00005012220
 protein coding gene Chr1:71494851-71603469 (-)



Homology
more
  • Human Ortholog
    USP37, ubiquitin specific peptidase 37
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP37, ubiquitin specific peptidase 37
  • Links
    NCBI Gene ID: 57695
    UniProt: Q86T82

  • Chr Location
    2q35; chr2:218450251-218568768 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    52
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    5
  • Gene trapped
    42
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Usp37
  • Incidental Mutations
    Mutagenetix , APF , CvDC
  • Find Mice (IMSR)
    61 strains or lines available
Mice homozygous for an ENU-induced mutation exhibit complete embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033364 Ensembl Gene Model | MGI Sequence Detail 108774 C57BL/6J ±  kb
transcript ENSMUST00000189257 Ensembl | MGI Sequence Detail 4974 Not Applicable  
polypeptide ENSMUSP00000140670 Ensembl | MGI Sequence Detail 979 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017176 ubiquitin carboxyl-terminal hydrolase 37
    (term hierarchy)
  • EC
    3.4.19.12
  • InterPro Domains
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR032069 Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain
    IPR038093 Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain superfamily
    IPR050164 Ubiquitin carboxyl-terminal hydrolases
    IPR003903 Ubiquitin interacting motif
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease USP, catalytic domain
  • GlyGen
    Q8C0R0 1 site
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 5
Other
Accession IDs
less
MGI:2442361
References
more
  • Summaries
    All 49
    Gene Ontology 6
    Phenotypes 23
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:381166 Gomez-Pascual A, et al., The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus. Cell Syst. 2026 Feb 18;17(2):101488
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory