About   Help   FAQ
Gimap5 Gene Detail
Summary
  • Symbol
    Gimap5
  • Name
    GTPase, IMAP family member 5
  • Synonyms
    E230026N22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442232
    NCBI Gene: 317757
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:48723131-48731134 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 23.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442232
 protein coding gene Chr6:48723131-48731144 (+)
129S1/SvImJ ENSMUSG00200005056
 protein coding gene Chr6:45628834-45636848 (+)
A/J ENSMUSG00195006752
 protein coding gene Chr6:45400393-45408573 (+)
AKR/J ENSMUSG00220003387
 protein coding gene Chr6:45110932-45118993 (+)
BALB/cJ ENSMUSG00180020836
 protein coding gene Chr6:45714360-45722421 (+)
C3H/HeJ ENSMUSG00175016171
 protein coding gene Chr6:45475977-45484039 (+)
C57BL/6NJ ENSMUSG00215007003
 protein coding gene Chr6:45673883-45681896 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028354
 protein coding gene Chr6:43165672-43173796 (+)
CAST/EiJ ENSTCUG00005004559
 protein coding gene Chr6:44989835-44998268 (+)
CBA/J ENSMUSG00210018133
 protein coding gene Chr6:45520827-45528890 (+)
DBA/2J ENSMUSG00185012722
 protein coding gene Chr6:46102523-46110583 (+)
FVB/NJ ENSMUSG00205018107
 protein coding gene Chr6:45766980-45775042 (+)
JF1/MsJ ENSUMUG00000008661
 protein coding gene Chr6:45462124-45470214 (+)
LP/J ENSMUSG00230017966
 protein coding gene Chr6:47125939-47133952 (+)
NOD/ShiLtJ ENSMUSG00190024751
 protein coding gene Chr6:45439633-45447813 (+)
NZO/HlLtJ ENSMUSG00225015941
 protein coding gene Chr6:49162493-49170506 (+)
PWK/PhJ ENSLUMG00010020729
 protein coding gene Chr6:45096341-45104440 (+)
SPRET/EiJ ENSMSPG00010009505
 protein coding gene Chr6:45721290-45727902 (+)
WSB/EiJ ENSIUOG00005025778
 protein coding gene Chr6:45736903-45744957 (+)



Homology
more
  • Human Ortholog
    GIMAP5, GTPase, IMAP family member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GIMAP5, GTPase, IMAP family member 5
  • Synonyms
    HIMAP3, IAN4, IAN4L1, IAN-5, IAN5, IMAP3, IROD, NCPH2
  • Links
    NCBI Gene ID: 55340
    UniProt: Q96F15

  • Chr Location
    7q36.1; chr7:150722253-150750033 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GIMAP5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    72 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygouse for a knock-out allele display defects in lymphocyte development with hematopoietic defects and reduced life span. Mice homozygous for an ENU-induced allele exhibit premature death associated with extramedullary hematopoiesis in the liver, anemia, cachexia, and colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 317757 NCBI Gene Model | MGI Sequence Detail 8004 C57BL/6J ±  kb
    transcript NM_001446464 RefSeq | MGI Sequence Detail 4281 C57BL/6  
    polypeptide Q8BWF2 UniProt | EBI | MGI Sequence Detail 308 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR006703 AIG1-type guanine nucleotide-binding (G) domain
      IPR045058 GTPase GIMA/IAN/Toc
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:62678 Phillips RL, et al., The genetic program of hematopoietic stem cells. Science. 2000 Jun 2;288(5471):1635-40
    • Latest
      J:355744 Drzewiecki K, et al., GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension. J Exp Med. 2021 Jul 5;218(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory