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Insyn1 Gene Detail
Summary
  • Symbol
    Insyn1
  • Name
    inhibitory synaptic factor 1
  • Synonyms
    6030419C18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442108
    NCBI Gene: 319477
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:58395886-58407063 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.79 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    269 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442108
 protein coding gene Chr9:58395886-58407063 (+)
129S1/SvImJ ENSMUSG00200032626
 protein coding gene Chr9:55523118-55534265 (+)
A/J ENSMUSG00195034100
 protein coding gene Chr9:55230229-55241376 (+)
AKR/J ENSMUSG00220030109
 protein coding gene Chr9:55364909-55376078 (+)
BALB/cJ ENSMUSG00180015746
 protein coding gene Chr9:55337623-55348803 (+)
C3H/HeJ ENSMUSG00175019074
 protein coding gene Chr9:55356938-55368086 (+)
C57BL/6NJ ENSMUSG00215029551
 protein coding gene Chr9:55330947-55342128 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032294
 protein coding gene Chr9:55180767-55191838 (+)
CAST/EiJ ENSTCUG00005018717
 protein coding gene Chr9:55256300-55267494 (+)
CBA/J ENSMUSG00210039237
 protein coding gene Chr9:55465432-55476592 (+)
DBA/2J ENSMUSG00185036715
 protein coding gene Chr9:55482244-55493389 (+)
FVB/NJ ENSMUSG00205033077
 protein coding gene Chr9:55788180-55799351 (+)
JF1/MsJ ENSUMUG00000046712
 protein coding gene Chr9:55499531-55510714 (+)
LP/J ENSMUSG00230032902
 protein coding gene Chr9:55722808-55733953 (+)
NOD/ShiLtJ ENSMUSG00190032693
 protein coding gene Chr9:55549313-55560482 (+)
NZO/HlLtJ ENSMUSG00225026777
 protein coding gene Chr9:55768036-55779195 (+)
PWK/PhJ ENSLUMG00010031524
 protein coding gene Chr9:55459893-55471102 (+)
SPRET/EiJ ENSMSPG00010026216
 protein coding gene Chr9:56497679-56507855 (+)
WSB/EiJ ENSIUOG00005037702
 protein coding gene Chr9:54963025-54974153 (+)



Homology
more
  • Human Ortholog
    INSYN1, inhibitory synaptic factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INSYN1, inhibitory synaptic factor 1
  • Synonyms
    C15orf59
  • Links
    NCBI Gene ID: 388135
    UniProt: Q2T9L4

  • Chr Location
    15q24.1; chr15:73735441-73753351 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit elevated neuronal firing patterns in the hippocampus and deficits in fear conditioning memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 319477 NCBI Gene Model | MGI Sequence Detail 11178 C57BL/6J ±  kb
    transcript NM_176921 RefSeq | MGI Sequence Detail 2177 C57BL/6  
    polypeptide Q8CD60 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      Genomic 1
      cDNA 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:6162261
    References
    more
    • Summaries
      All 23
      Gene Ontology 4
      Phenotypes 5
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:284536 Uezu A, et al., Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice. Elife. 2019 Dec 12;8:e50712
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory