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Mrgpre Gene Detail
Summary
  • Symbol
    Mrgpre
  • Name
    MAS-related GPR, member E
  • Synonyms
    C130069N09Rik, MrgE
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441884
    NCBI Gene: 244238
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:143332100-143338237 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 88.31 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    276 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441884
 protein coding gene Chr7:143332100-143338237 (-)
129S1/SvImJ ENSMUSG00200041264
 protein coding gene Chr7:129898719-129904858 (-)
A/J ENSMUSG00195001731
 protein coding gene Chr7:134380898-134387037 (-)
AKR/J ENSMUSG00220025499
 protein coding gene Chr7:127863096-127869233 (-)
BALB/cJ ENSMUSG00180038630
 protein coding gene Chr7:131068755-131074892 (-)
C3H/HeJ ENSMUSG00175004041
 protein coding gene Chr7:131801736-131807875 (-)
C57BL/6NJ ENSMUSG00215043974
 protein coding gene Chr7:131068093-131074232 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030748
 protein coding gene Chr7:145946144-145952167 (-)
CAST/EiJ ENSTCUG00005002745
 protein coding gene Chr7:134399368-134405422 (-)
CBA/J ENSMUSG00210003626
 protein coding gene Chr7:131559611-131565749 (-)
DBA/2J ENSMUSG00185013849
 protein coding gene Chr7:135838272-135844412 (-)
FVB/NJ ENSMUSG00205002006
 protein coding gene Chr7:131480345-131486486 (-)
JF1/MsJ ENSUMUG00000039247
 protein coding gene Chr7:140876802-140882873 (-)
LP/J ENSMUSG00230007082
 protein coding gene Chr7:142001494-142007631 (-)
NOD/ShiLtJ ENSMUSG00190003830
 protein coding gene Chr7:131667091-131673230 (-)
NZO/HlLtJ ENSMUSG00225050298
 protein coding gene Chr7:140210417-140216555 (-)
PWK/PhJ ENSLUMG00010038434
 protein coding gene Chr7:130048898-130054952 (-)
SPRET/EiJ ENSMSPG00010000991
 protein coding gene Chr7:131620564-131624681 (-)
WSB/EiJ ENSIUOG00005000903
 protein coding gene Chr7:132462460-132468596 (-)



Homology
more
  • Human Ortholog
    MRGPRE, MAS related GPR family member E
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRGPRE, MAS related GPR family member E
  • Synonyms
    GPR167, MGRF, MRGE
  • Links
    NCBI Gene ID: 116534
    UniProt: Q86SM8

  • Chr Location
    11p15.4; chr11:3225030-3232417 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit alterations in the development but not maintenance of allodynia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    668
  • Tissues
    32
  • cDNA Data
    11
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 244238 NCBI Gene Model | MGI Sequence Detail 6138 C57BL/6J ±  kb
    transcript NM_175534 RefSeq | MGI Sequence Detail 3777 C57BL/6  
    polypeptide Q91ZB7 UniProt | EBI | MGI Sequence Detail 310 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:71586 Dong X, et al., A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 2001 Sep 7;106(5):619-32
    • Latest
      J:371190 Lin J, et al., A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE. Cell. 2025 Aug 21;188(17):4530-4548.e25
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory