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Eif5b Gene Detail
Summary
  • Symbol
    Eif5b
  • Name
    eukaryotic translation initiation factor 5B
  • Synonyms
    A030003E17Rik, IF2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441772
    NCBI Gene: 226982
  • Alliance
  • Transcription Start Sites
    41 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:38037091-38094660 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 16.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1204 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441772
protein coding gene Chr1:38037091-38094660 (+)
129S1/SvImJ ENSMUSG00200004045
protein coding gene Chr1:35627301-35684881 (+)
A/J ENSMUSG00195041033
protein coding gene Chr1:35276297-35333758 (+)
AKR/J ENSMUSG00220008953
protein coding gene Chr1:35292308-35351960 (+)
BALB/cJ ENSMUSG00180011640
protein coding gene Chr1:35372814-35430424 (+)
C3H/HeJ ENSMUSG00175001319
protein coding gene Chr1:35279964-35337421 (+)
C57BL/6NJ ENSMUSG00215028122
protein coding gene Chr1:35349756-35407363 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014061
protein coding gene Chr1:32629119-32689233 (+)
CAST/EiJ ENSTCUG00005002711
protein coding gene Chr1:35424481-35482087 (+)
CBA/J ENSMUSG00210005746
protein coding gene Chr1:35104783-35164422 (+)
DBA/2J ENSMUSG00185009624
protein coding gene Chr1:36204407-36264030 (+)
FVB/NJ ENSMUSG00205024232
protein coding gene Chr1:35302636-35360215 (+)
JF1/MsJ ENSUMUG00000006902
protein coding gene Chr1:35405650-35463425 (+)
LP/J ENSMUSG00230020991
protein coding gene Chr1:36248130-36305734 (+)
NOD/ShiLtJ ENSMUSG00190023707
protein coding gene Chr1:35310617-35368073 (+)
NZO/HlLtJ ENSMUSG00225013315
protein coding gene Chr1:39489129-39546728 (+)
PWK/PhJ ENSLUMG00010030461
protein coding gene Chr1:34948695-35006342 (+)
SPRET/EiJ ENSMSPG00010025148
protein coding gene Chr1:36429798-36482038 (+)
WSB/EiJ ENSIUOG00005033628
protein coding gene Chr1:35236205-35293839 (+)



Homology
more
  • Human Ortholog
    EIF5B, eukaryotic translation initiation factor 5B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF5B, eukaryotic translation initiation factor 5B
  • Synonyms
    IF2
  • Links
    NCBI Gene ID: 9669
    UniProt: O60841

  • Chr Location
    2q11.2; chr2:99337371-99401326 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show embryonic growth retardation and lethality before implantation. In vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming blastocysts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 226982 NCBI Gene Model | MGI Sequence Detail 57570 C57BL/6J ±  kb
transcript NM_198303 RefSeq | MGI Sequence Detail 7797 C57BL/6  
polypeptide Q05D44 UniProt | EBI | MGI Sequence Detail 1216 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000007006 eukaryotic translation initiation factor 5B
  • EC
  • InterPro Domains
    IPR029459 Elongation factor Tu-type domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR005225 Small GTP-binding domain
    IPR000795 Translational (tr)-type GTP-binding domain
    IPR015760 Translation initiation factor IF- 2
    IPR023115 Translation initiation factor IF- 2, domain 3
    IPR036925 Translation initiation factor IF-2, domain 3 superfamily
    IPR009000 Translation protein, beta-barrel domain superfamily
  • GlyGen
    Q05D44 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 5
Other
Accession IDs
less
MGI:2448517
References
more
  • Summaries
    All 47
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
09/08/2026
MGI 6.24
The Jackson Laboratory