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Adamtsl4 Gene Detail
Summary
  • Symbol
    Adamtsl4
  • Name
    ADAMTS-like 4
  • Synonyms
    Tsrc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389008
    NCBI Gene: 229595
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95583511-95595228 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    334 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2389008
 protein coding gene Chr3:95583511-95595232 (-)
129S1/SvImJ ENSMUSG00200041464
 protein coding gene Chr3:92242139-92253842 (-)
A/J ENSMUSG00195042546
 protein coding gene Chr3:92566408-92578123 (-)
AKR/J ENSMUSG00220032511
 protein coding gene Chr3:90953439-90965165 (-)
BALB/cJ ENSMUSG00180039569
 protein coding gene Chr3:92565877-92577598 (-)
C3H/HeJ ENSMUSG00175025768
 protein coding gene Chr3:92210072-92221785 (-)
C57BL/6NJ ENSMUSG00215030718
 protein coding gene Chr3:92928871-92940591 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025350
 protein coding gene Chr3:89758109-89769961 (-)
CAST/EiJ ENSTCUG00005045346
 protein coding gene Chr3:92760850-92772674 (-)
CBA/J ENSMUSG00210051059
 protein coding gene Chr3:92747531-92759242 (-)
DBA/2J ENSMUSG00185042108
 protein coding gene Chr3:93164176-93175897 (-)
FVB/NJ ENSMUSG00205035608
 protein coding gene Chr3:91860788-91872509 (-)
JF1/MsJ ENSUMUG00000044591
 protein coding gene Chr3:92054307-92066222 (-)
LP/J ENSMUSG00230040732
 protein coding gene Chr3:95105562-95117263 (-)
NOD/ShiLtJ ENSMUSG00190045436
 protein coding gene Chr3:93263756-93275681 (-)
NZO/HlLtJ ENSMUSG00225012203
 protein coding gene Chr3:97527604-97539323 (-)
PWK/PhJ ENSLUMG00010050036
 protein coding gene Chr3:92034633-92046539 (-)
SPRET/EiJ ENSMSPG00010040542
 protein coding gene Chr3:92333893-92346040 (-)
WSB/EiJ ENSIUOG00005027392
 protein coding gene Chr3:92684078-92695775 (-)



Homology
more
  • Human Ortholog
    ADAMTSL4, ADAMTS like 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTSL4, ADAMTS like 4
  • Synonyms
    ADAMTSL-4, ECTOL2, TSRC1
  • Links
    NCBI Gene ID: 54507
    UniProt: Q6UY14

  • Chr Location
    1q21.2; chr1:150549369-150560937 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Adamtsl4 mouse models; 2 with human ADAMTSL4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced single point mutation exhibit ectopia lentis, increased ocular axial length, and focal retinal pigment epithelium defects with reduced retinal pigmentation and altered cellular morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    643
  • Tissues
    31
  • cDNA Data
    19
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015850 Ensembl Gene Model | MGI Sequence Detail 11718 C57BL/6J ±  kb
    transcript ENSMUST00000117782 Ensembl | MGI Sequence Detail 4036 Not Applicable  
    polypeptide ENSMUSP00000113424 Ensembl | MGI Sequence Detail 1036 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 19
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory