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Klhl11 Gene Detail
Summary
  • Symbol
    Klhl11
  • Name
    kelch-like 11
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388648
    NCBI Gene: 217194
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100353440-100363567 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    199 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2388648
 protein coding gene Chr11:100347948-100363608 (-)
129S1/SvImJ ENSMUSG00200050621
 protein coding gene Chr11:97623438-97633566 (-)
A/J ENSMUSG00195050665
 protein coding gene Chr11:97321761-97331891 (-)
AKR/J ENSMUSG00220047565
 protein coding gene Chr11:97557199-97567324 (-)
BALB/cJ ENSMUSG00180050029
 protein coding gene Chr11:97685301-97695429 (-)
C3H/HeJ ENSMUSG00175051507
 protein coding gene Chr11:97596989-97607117 (-)
C57BL/6NJ ENSMUSG00215050521
 protein coding gene Chr11:97172463-97182590 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017174
 protein coding gene Chr11:96331280-96341402 (-)
CAST/EiJ ENSTCUG00005049619
 protein coding gene Chr11:97102521-97112719 (-)
CBA/J ENSMUSG00210052047
 protein coding gene Chr11:97318628-97328756 (-)
DBA/2J ENSMUSG00185046428
 protein coding gene Chr11:97646878-97657006 (-)
FVB/NJ ENSMUSG00205046935
 protein coding gene Chr11:97503384-97513511 (-)
JF1/MsJ ENSUMUG00000041201
 protein coding gene Chr11:97898156-97908273 (-)
LP/J ENSMUSG00230045318
 protein coding gene Chr11:98699598-98709726 (-)
NOD/ShiLtJ ENSMUSG00190045362
 protein coding gene Chr11:97682929-97693058 (-)
NZO/HlLtJ ENSMUSG00225050673
 protein coding gene Chr11:100735458-100745586 (-)
PWK/PhJ ENSLUMG00010048002
 protein coding gene Chr11:97454141-97464255 (-)
SPRET/EiJ ENSMSPG00010049270
 protein coding gene Chr11:97943744-97954076 (-)
WSB/EiJ ENSIUOG00005048838
 protein coding gene Chr11:97447935-97458064 (-)



Homology
more
  • Human Ortholog
    KLHL11, kelch like family member 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLHL11, kelch like family member 11
  • Links
    NCBI Gene ID: 55175
    UniProt: Q9NVR0

  • Chr Location
    17q21.2; chr17:41848518-41865423 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    23
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048732 Ensembl Gene Model | MGI Sequence Detail 10128 C57BL/6J ±  kb
transcript ENSMUST00000056665 Ensembl | MGI Sequence Detail 2393 Not Applicable  
polypeptide ENSMUSP00000054963 Ensembl | MGI Sequence Detail 709 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 2
References
more
  • Summaries
    All 35
    Gene Ontology 1
    Phenotypes 14
  • Earliest
    J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
  • Latest
    J:232020 Ermakova O, et al., Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice. EMBO Mol Med. 2011 Jan;3(1):50-66
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory