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Pofut3 Gene Detail
Summary
  • Symbol
    Pofut3
  • Name
    protein O-fucosyltransferase 3
  • Synonyms
    Fut10, MGC:40819
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384748
    NCBI Gene: 171167
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:31677359-31751766 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 18.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2830 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384748
 protein coding gene Chr8:31677342-31757310 (+)
129S1/SvImJ ENSMUSG00200021528
 protein coding gene Chr8:26753799-26827943 (+)
A/J ENSMUSG00195005339
 protein coding gene Chr8:27246775-27320972 (+)
AKR/J ENSMUSG00220023084
 protein coding gene Chr8:27018400-27092493 (+)
BALB/cJ ENSMUSG00180005468
 protein coding gene Chr8:26793807-26867997 (+)
C3H/HeJ ENSMUSG00175006305
 protein coding gene Chr8:26932096-27006181 (+)
C57BL/6NJ ENSMUSG00215010990
 protein coding gene Chr8:26744101-26818792 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030958
 protein coding gene Chr8:25302267-25377160 (+)
CAST/EiJ ENSTCUG00005021177
 protein coding gene Chr8:26925621-27000980 (+)
CBA/J ENSMUSG00210013171
 protein coding gene Chr8:26775817-26849994 (+)
DBA/2J ENSMUSG00185001978
 protein coding gene Chr8:32706511-32780596 (+)
FVB/NJ ENSMUSG00205003185
 protein coding gene Chr8:25988691-26062873 (+)
JF1/MsJ ENSUMUG00000005622
 protein coding gene Chr8:34404977-34479677 (+)
LP/J ENSMUSG00230014792
 protein coding gene Chr8:36361498-36435649 (+)
NOD/ShiLtJ ENSMUSG00190003993
 protein coding gene Chr8:26817670-26891852 (+)
NZO/HlLtJ ENSMUSG00225019790
 protein coding gene Chr8:39957354-40032022 (+)
PWK/PhJ ENSLUMG00010025481
 protein coding gene Chr8:26679240-26753708 (+)
SPRET/EiJ ENSMSPG00010015862
 protein coding gene Chr8:27361733-27425353 (+)
WSB/EiJ ENSIUOG00005009749
 protein coding gene Chr8:27514083-27584530 (+)



Homology
more
  • Human Ortholog
    POFUT3, protein O-fucosyltransferase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POFUT3, protein O-fucosyltransferase 3
  • Synonyms
    FUCTX, FUT10
  • Links
    NCBI Gene ID: 84750
    UniProt: Q6P4F1

  • Chr Location
    8p12; chr8:33308061-33473146 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    29
  • cDNA Data
    33
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046152 Ensembl Gene Model | MGI Sequence Detail 74408 C57BL/6J ±  kb
transcript ENSMUST00000066173 Ensembl | MGI Sequence Detail 3183 Not Applicable  
polypeptide ENSMUSP00000069816 Ensembl | MGI Sequence Detail 481 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    cDNA 33

    Microarray probesets 5
Other
Accession IDs
less
MGI:8207903
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 4
  • Earliest
    J:74415 Roos C, et al., Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. J Biol Chem. 2002 Feb 1;277(5):3168-75
  • Latest
    J:364518 Hao H, et al., FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains. Nat Chem Biol. 2025 Apr;21(4):598-610
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory