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Armc5 Gene Detail
Summary
  • Symbol
    Armc5
  • Name
    armadillo repeat containing 5
  • Synonyms
    MGC:36606
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384586
    NCBI Gene: 233912
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127836514-127844272 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 70.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384586
 protein coding gene Chr7:127836460-127844272 (+)
129S1/SvImJ ENSMUSG00200021601
 protein coding gene Chr7:114349370-114359650 (+)
A/J ENSMUSG00195038118
 protein coding gene Chr7:118847967-118858403 (+)
AKR/J ENSMUSG00220015978
 protein coding gene Chr7:112302364-112312800 (+)
BALB/cJ ENSMUSG00180012226
 protein coding gene Chr7:115543188-115553624 (+)
C3H/HeJ ENSMUSG00175013375
 protein coding gene Chr7:116270024-116280460 (+)
C57BL/6NJ ENSMUSG00215025011
 protein coding gene Chr7:115546168-115556680 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030542
 protein coding gene Chr7:130264159-130271514 (+)
CAST/EiJ ENSTCUG00005048221
 protein coding gene Chr7:118726367-118796201 (+)
CBA/J ENSMUSG00210023112
 protein coding gene Chr7:116027134-116037646 (+)
DBA/2J ENSMUSG00185039404
 protein coding gene Chr7:120340000-120350512 (+)
FVB/NJ ENSMUSG00205016073
 protein coding gene Chr7:115978324-115989226 (+)
JF1/MsJ ENSUMUG00000011609
 protein coding gene Chr7:125363815-125374094 (+)
LP/J ENSMUSG00230051771
 protein coding gene Chr7:126447883-126458162 (+)
NOD/ShiLtJ ENSMUSG00190015260
 protein coding gene Chr7:116171340-116182387 (+)
NZO/HlLtJ ENSMUSG00225011319
 protein coding gene Chr7:124683261-124693697 (+)
PWK/PhJ ENSLUMG00010035121
 protein coding gene Chr7:114516976-114527256 (+)
SPRET/EiJ ENSMSPG00010011481
 protein coding gene Chr7:115777625-115787863 (+)
WSB/EiJ ENSIUOG00005025785
 protein coding gene Chr7:116875025-116885462 (+)



Homology
more
  • Human Ortholog
    ARMC5, armadillo repeat containing 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARMC5, armadillo repeat containing 5
  • Synonyms
    AIMAH2
  • Links
    NCBI Gene ID: 79798
    UniProt: Q96C12

  • Chr Location
    16p11.2; chr16:31458080-31467172 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ARMC5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality with defects in mesoderm formation and gastrulation. The few survbiving mice are smaller than normal. Mice heterozygous for the same allele exhibit abnormal adrenocortical morphology and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    602
  • Tissues
    1
  • cDNA Data
    33
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042178 Ensembl Gene Model | MGI Sequence Detail 7759 C57BL/6J ±  kb
    transcript ENSMUST00000044660 Ensembl | MGI Sequence Detail 3834 Not Applicable  
    polypeptide ENSMUSP00000040568 Ensembl | MGI Sequence Detail 926 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 33

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142196
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:359500 Uota A, et al., ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes. J Biol Chem. 2024 Nov 2;300(12):107953
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory