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Kat7 Gene Detail
Summary
  • Symbol
    Kat7
  • Name
    K(lysine) acetyltransferase 7
  • Synonyms
    Hbo1, Hboa, MGC:56758, Myst2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182799
    NCBI Gene: 217127
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:95165085-95201072 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    971 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182799
 protein coding gene Chr11:95162683-95201072 (-)
129S1/SvImJ ENSMUSG00200047890
 protein coding gene Chr11:92408429-92444416 (-)
A/J ENSMUSG00195048965
 protein coding gene Chr11:92131270-92167557 (-)
AKR/J ENSMUSG00220045734
 protein coding gene Chr11:92390174-92426464 (-)
BALB/cJ ENSMUSG00180044280
 protein coding gene Chr11:92377142-92413110 (-)
C3H/HeJ ENSMUSG00175049212
 protein coding gene Chr11:92390696-92426988 (-)
C57BL/6NJ ENSMUSG00215053226
 protein coding gene Chr11:91981460-92017451 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017004
 protein coding gene Chr11:91020967-91057289 (-)
CAST/EiJ ENSTCUG00005015430
 protein coding gene Chr11:91839512-91875374 (-)
CBA/J ENSMUSG00210051432
 protein coding gene Chr11:92094084-92130371 (-)
DBA/2J ENSMUSG00185041182
 protein coding gene Chr11:92430170-92466159 (-)
FVB/NJ ENSMUSG00205039874
 protein coding gene Chr11:92295432-92331421 (-)
JF1/MsJ ENSUMUG00000037036
 protein coding gene Chr11:92746254-92782544 (-)
LP/J ENSMUSG00230045298
 protein coding gene Chr11:93491633-93527620 (-)
NOD/ShiLtJ ENSMUSG00190044262
 protein coding gene Chr11:92470916-92506883 (-)
NZO/HlLtJ ENSMUSG00225050963
 protein coding gene Chr11:95538554-95574542 (-)
PWK/PhJ ENSLUMG00010027871
 protein coding gene Chr11:92294237-92330546 (-)
SPRET/EiJ ENSMSPG00010046503
 protein coding gene Chr11:92775028-92810152 (-)
WSB/EiJ ENSIUOG00005041880
 protein coding gene Chr11:92240681-92276713 (-)



Homology
more
  • Human Ortholog
    KAT7, lysine acetyltransferase 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KAT7, lysine acetyltransferase 7
  • Synonyms
    HBO1, HBOA, MYST2, ZC2HC7
  • Links
    NCBI Gene ID: 11143
    UniProt: O95251

  • Chr Location
    17q21.33; chr17:49788624-49835026 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic growth arrest, incomplete embryo turning, disorganized yolk sac vascular plexus, and increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    118
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    665
  • Tissues
    51
  • cDNA Data
    17
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038909 Ensembl Gene Model | MGI Sequence Detail 35988 C57BL/6J ±  kb
    transcript ENSMUST00000249615 Ensembl | MGI Sequence Detail 3560 Not Applicable  
    polypeptide ENSMUSP00000159824 Ensembl | MGI Sequence Detail 637 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 17
      Primer pair 3
      Other 1
      Antibodies 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 15
      Gene Ontology 15
      Phenotypes 22
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:387442 Liu Y, et al., Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer's disease pathogenesis. Neuron. 2026 Jun 9;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory