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Nt5c2 Gene Detail
Summary
  • Symbol
    Nt5c2
  • Name
    5'-nucleotidase, cytosolic II
  • Synonyms
    cN-II, NT5B, PNT5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178563
    NCBI Gene: 76952
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:46873829-47003613 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.97 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3383 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2178563
 protein coding gene Chr19:46871756-47003613 (-)
129S1/SvImJ ENSMUSG00200021015
 protein coding gene Chr19:43577614-43709630 (-)
A/J ENSMUSG00195016104
 protein coding gene Chr19:43707981-43839857 (-)
AKR/J ENSMUSG00220017976
 protein coding gene Chr19:43513723-43645372 (-)
BALB/cJ ENSMUSG00180016812
 protein coding gene Chr19:43960066-44091935 (-)
C3H/HeJ ENSMUSG00175006405
 protein coding gene Chr19:43506526-43638273 (-)
C57BL/6NJ ENSMUSG00215004515
 protein coding gene Chr19:43570474-43702332 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023046
 protein coding gene Chr19:43550377-43692179 (-)
CAST/EiJ ENSTCUG00005015236
 protein coding gene Chr19:43168500-43300176 (-)
CBA/J ENSMUSG00210018674
 protein coding gene Chr19:43586025-43717778 (-)
DBA/2J ENSMUSG00185007954
 protein coding gene Chr19:44083443-44215317 (-)
FVB/NJ ENSMUSG00205028371
 protein coding gene Chr19:43003691-43133586 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230020417
 protein coding gene Chr19:44847213-44979231 (-)
NOD/ShiLtJ ENSMUSG00190005347
 protein coding gene Chr19:43450513-43582148 (-)
NZO/HlLtJ ENSMUSG00225043170
 protein coding gene Chr19:48443274-48574972 (-)
PWK/PhJ ENSLUMG00010000961
 protein coding gene Chr19:43406147-43540607 (-)
SPRET/EiJ ENSMSPG00010007272
 protein coding gene Chr19:43135046-43275539 (-)
WSB/EiJ ENSIUOG00005006483
 protein coding gene Chr19:42956845-43088449 (-)



Homology
more
  • Human Ortholog
    NT5C2, 5'-nucleotidase, cytosolic II
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NT5C2, 5'-nucleotidase, cytosolic II
  • Synonyms
    cN-II, GMP, NT5B, PNT5, SPG45, SPG65
  • Links
    NCBI Gene ID: 22978
    UniProt: P49902

  • Chr Location
    10q24.32-q24.33; chr10:103087141-103277605 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NT5C2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Bone marrow cells with a nucleotide substitution allele used in a transplantation experiment following tamoxifen-induction produce NOTCH1-induced tumors that are resistant to 6-mercaptopurine chemotherapy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    96
  • cDNA Data
    16
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76952 NCBI Gene Model | MGI Sequence Detail 129785 C57BL/6J ±  kb
    transcript NR_165074 RefSeq | MGI Sequence Detail 5860 C57BL/6  
    polypeptide Q3V1L4 UniProt | EBI | MGI Sequence Detail 560 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924202
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 3
      Gene Ontology 13
      Phenotypes 14
    • Earliest
      J:297459 Magnusson G, Deoxyribonucleotide phosphatase from rat liver and cultured mouse fibroblasts. Eur J Biochem. 1971 May 28;20(2):225-30
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory